Desmopressin Acetate

Desmopressin Acetate

Contact : Mr.Thyen-------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details


Desmopressin Acetate

Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


CAS No.: 16789-98-3
MW: 1069.24
MF: C46H64N14O12S2
Category:Generic Peptide
Min order: 1 gram
Purity: 98%+

 

What is Desmopressin Acetate?

Desmopressin acetate (trade names: DDAVP, Stimate, Minirin) is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as a tablet. Doctors prescribe Desmopressin most frequently for treatment of diabetes insipidus or nocturnal enuresis. Desmopressin (1-desamino-8-D-arginine vasopressin) is a modified form of the normal human hormone arginine vasopressin, a peptide containing nine amino acids. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) nighttime urination; (c) clotting disorders; (d) diabetes insipidus .

 

Desmopressin Acetate Specification

Purity (HPLC) 98.0%min. 
Appearance White powder 
Single Impurity (HPLC) 0.5%max 
Amino Acid Composition   ±10% of theoretical 
Peptide Content (N%)  ≥80.0% 
Water Content (Karl Fischer)   ≤8.0% 
Acetate Content (HPIC) ≤12.0% 
MS (ESI) Consistent 
Mass Balance 95.0~105.0% 

 

Desmopressin Acetate Application

1. Bed wetting


Desmopressin is used to treat nocturnal enuresis (bedwetting). It is usually prescribed in the form of oral desmopressin acetate, DDAVP. Children taking DDAVP have 2.2 fewer wet nights per week and are 4.5 times more likely to sleep without disruption compared with placebo.


2. Nighttime urination
Desmopressin has some benefit in adults who have problems with night time urination (known as nocturia).
Clotting disorders Desmopressin (DDAVP) stimulates the release of von Willebrand factor (vWF) from the Weibel-Palade_body bodies ofendothelial cells, thereby increasing the levels of vWF (as well as coagulant factor VIII) 3 to 5-fold. Desmopressin can be used to promote the release of von Willebrand factor (with subsequent increase in factor VIII survival secondary to vWF complexing) in patients with coagulation disorders such as von Willebrand disease, mild hemophilia A (factor VIII deficiency), and thrombocytopenia. It can be used with uremic induced platelet dysfunction. It is not effective in the treatment of hemophilia B (factor IX deficiency) or severe hemophilia A.


3. Diabetes insipidus
Desmopressin is used in the treatment of central diabetes insipidus (DI), to replace endogenous antidiuretic hormone(ADH) that is missing in the central nervous system type of this disorder (decreased production of ADH from the posterior pituitary). It is also used in the diagnostic workup for diabetes insipidus, in order to distinguish central from nephrogenic DI.

 

Attention: Desmopressin Acetate is a custom product which need about 4 weeks to complete customization. MOQ 1g.

 

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