Fertirelin Acetate 38234-21-8
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| Product Name | Fertirelin Acetate |
| Sequence | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt |
| Cas No. | 38234-21-8 |
| Molecular Formula | C55H76N16O12 |
| Molecular Weight | 1153.26 |
| Purity (HPLC) | 99.0% |
| Appearance | White powder |
| Single Impurity(HPLC) | 1.0% |
| Amino Acid Composition | 10% of theoretical |
| Peptide Content(N%) | 80%(by %N) |
| Water Content(Karl Fischer) | 6.0% |
| Acetate Content(HPIC) | 15.0% |
| Mass Balance | 95.0~105.0% |
Fertirelin Acetate ----Detailed Description:
Fertirelin is a synthetic luteinizing hormone-releasing hormone (LH-RH) analogue, and Fertirelin is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Fertirelin was administered at the beginning of the protocol followed 7 days later by 500 μ G cloprosterol.
The conception rate did not differ between the 50 μ G fertirelin group (61.1%; N = 72) and the 100 μ G group. Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus.
COA
| Molecular Formula | C55H76N16O12 |
| Molecular Weight | 1153.26 |
| Purity (HPLC) | 99.0% |
| Appearance | White powder |
| Single Impurity(HPLC) | 1.0% |
| Amino Acid Composition | 10% of theoretical |
| Peptide Content(N%) | 80%(by %N) |
| Water Content(Karl Fischer) | 6.0% |
| Acetate Content(HPIC) | 15.0% |
| MS(ESI) | |
| Mass Balance | 95.0~105.0% |
Fertirelin Acetate ----Applications:
Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine.
Fertirelin Acetate ----Uasge:
An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstrictio n via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension.
Fertirelin Acetate ----Indications
· To supplement LH in cases of ovulation failure.
· To induce lactation post partum.
· Management of genital hypoplasia and reduced libido in males.
· To manange signs of estrus in ferrets.
