Fertirelin Acetate 38234-21-8

Fertirelin Acetate 38234-21-8

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details

Fertirelin Acetate 38234-21-8

Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Product NameFertirelin Acetate 
SequencePyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt
Cas No. 38234-21-8
Molecular FormulaC55H76N16O12
Molecular Weight1153.26
Purity (HPLC)99.0%
Appearance White powder
Single Impurity(HPLC) 1.0%
Amino Acid Composition 10% of theoretical
Peptide Content(N%)80%(by %N)
Water Content(Karl Fischer) 6.0%
Acetate Content(HPIC)15.0%
Mass Balance 95.0~105.0%


Fertirelin Acetate ----Detailed Description:
 
Fertirelin is a synthetic luteinizing hormone-releasing hormone (LH-RH) analogue, and Fertirelin is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
 
Fertirelin was administered at the beginning of the protocol followed 7 days later by 500 μ G cloprosterol.
The conception rate did not differ between the 50 μ G fertirelin group (61.1%; N = 72) and the 100 μ G group. Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus.

COA

Molecular FormulaC55H76N16O12
Molecular Weight1153.26
Purity (HPLC)99.0%
Appearance White powder
Single Impurity(HPLC) 1.0%
Amino Acid Composition 10% of theoretical
Peptide Content(N%)80%(by %N)
Water Content(Karl Fischer) 6.0%
Acetate Content(HPIC)15.0%
MS(ESI)
Mass Balance 95.0~105.0%


Fertirelin Acetate ----Applications:

Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine.

Fertirelin Acetate ----Uasge:

An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstrictio n via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension.

Fertirelin Acetate ----Indications

· To supplement LH in cases of ovulation failure.
· To induce lactation post partum.
· Management of genital hypoplasia and reduced libido in males.
· To manange signs of estrus in ferrets.


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