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1) Hexarelin Details:
Synonyms: Hexarelin Acetate, HEX, Examorelin
Molecular formula: C47H58N12O6
Molar Mass: 887.04022
CAS number: 140703-51-1
Appearance: White powder
Peptide purity: > 98.0%
Related substance: Total Impurities(%) ≤ 2.0%
Bacterial Endotoxins: ≤5 IU/mg
2) Hexarelin Specification:
CAS register number
White crystalline powder
Amino Acid Composition
10% of theoretical
Peptide Content (N%)
Water Content(Karl Fischer)
3) The Functionality of Hexarelin:
Hexarelin (Hexarelin Acetate) is chemically designed as L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide. Hexarelin (Hexarelin Acetate) is a potent GHRP-6 analog,whose structure (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) creates a greater stability than GHRP-6 due to a substituted (2 Me)Trp. Hexarelin has a half-life of about 70 min, longer than that of GHRP-6. Replacement of the naturally occurring L-amino acids for the D-configuration results in these longer half-lives.
Hexarelin has shown that it is highly stimulated at 30 minutes after being induced by rapid and sustained GH secretion. The pituitary gland produces GH in the brain, in children this hormone helps them to grow and in adults it helps to maintain muscle and burn fat. In one sixteen-week study, it has been shown that GH levels return to normal after stopping use after four weeks.
4) What is Hexarelin?
Hexarelin (HEX) may be a amide GH secretagogue with a potent ability to stimulate GH secretion and recently reportable cardioprotective actions. as a result of Hexarelin’s aminoalkanoic acid sequence might facilitate in promoting the body to provide a lot of hormone, it’ll not finish off the body’s own production. Hexarelin may be a artificial amide composed of vi amino acids creating it a hexaptide with a structure that has been thought of to push the discharge of hormone. Effects from GH embody raised bone mineral density, raised cellular division and meiosis that ends up in a lot of muscle mass, acylglycerol chemical reaction that causes distinguished fat loss, animal tissue strengthening, and improved skin physical property. as a result of Hexarelin’s aminoalkanoic acid sequence might facilitate in promoting the body to provide a lot of hormone, it’ll not finish off the body’s own production. this is often a really necessary issue and makes Hexarelin a pretty chain compared to hormone alone.
For analysis functions solely. Hexarelin may be a non-natural (synthetic) hormone (GH)-releasing hexapeptide that belongs to the GHS family. This specific supermolecule has been found to act on each ductless gland and also the neural structure, however, its mechanisms of action within the human physiological system has not nonetheless been totally elucidated (Arvat et al. 1995).
This artificial amide has similar GH-secreting properties with its predecessors like the GHRP-6, GHRP-2 and GHRP-1. Hexarelin is GHRP analog during which the Trp was substituted with with chemicals a lot of table 2-Methyl-Trp (Denghenghi et al. 1994). The chemical structure of that is shown within the following: several studies on mice are disbursed double-geared towards deeper understanding of its chemical activity.
Hexarelin (HEX) may be a amide GH secretagogue with a potent ability to stimulate GH secretion and recently reportable cardioprotective actions. However, hexarelin (HEX) effects within the brain area unit mostly unknown, and also the aim of the current study was to look at the potential protecting impact of hexarelin (HEX) on the central systema nervosum once injury, also as on caspase-3, Akt, and animate thing signal-regulated supermolecule enzyme (ERK) signal cascades in an exceedingly rat model of babe hypoxia-ischemia.
5) Common dosage regimen of Peptides:
Cycle: 16 months. The dosage is prescribed individually and injected 1-6 times a day starting with 25-50mcg and gradually increasing it with the step of 25-50mcg to achieve minimal side effects. Then, there should be return to the starting dose. The injections are usually made subcutaneously in an abdominal area 30 minutes before or in 1-1.5 after meal. The time between injections should be 3-4 hours (in order the body has the time to produce GH for further release).
Hexarelin is a peptide structurally similar to GHRP-6, which stimulates secretion of endogenous GH. Hexarelin has the majority of synthetic GH effects, but these effects are less evident with Hexarelin than with GH. The main effects of Hexarelin include increase of strength, growth of new muscle fibers, improving of vessels state, reduction of fat mass. The main difference of Hexarelin from GHRP-6 is that Hexarelin does not promote appetite, because it does not increase the level of ghrelin in the body.
This drug proved to be a great healer of wounds and can be administered as a multipurpose anabolic and with the purpose to stimulate endogenous GH secretion inhibited with the use of synthetic GH.
Medicinally, Hexarelin can be used to treat GH deficiency induced diseases.