HGH Fragment (176-191)
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Hormone peptide fragment 176-191, also known as Frag 176-191, is a modified form of amino acids 176-191 of the GH polypeptide. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the Hormone molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Hormone. Like Hormone, the fragment 176-191 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat) both in laboratory testing and in animals and humans.
Laboratory Tests and Fat Loss
In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted Hormone effect. Research dosages of 500mcg of the fragment 176-191 daily for 30 days did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people.
Fragment 176-191 as an Active Truncated Peptide
Fragment 176-191 is an analog of the hormone-releasing factor (GRF) which signals the effects of hormone. It is a 15-mer peptide residue of the C-terminus of GH to which tyrosine is added at the N-terminal end. This synthetically produced hormone is very common to weightlifters and bodybuilders because of a number of physical benefits. Studies claimed that it actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body.
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