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|Usage||regulate the duodenum's pH|
|H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 , Hsdgtftsersrlrdsarlqllqglv-nh3 , Secretin, Pig secretin, Porcine secretin, Secrepan, Secretin-Ferring, Sekretolin , Tinacetate|
|Categories||Amino Acid Derivatives;Peptide;Peptides for Cell Biology;Gastrointestinal Peptides;SecretinPeptides for Cell Biology;Hormones;Other Protein/Peptide Hormones;Secretins|
Description of Secretin
1.Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene.
2.Secretin helps regulate the pH of the duodenum by inhibiting the secretion of gastric acid from the parietal cells of the stomach and stimulating the production of bicarbonate from the centroacinar cells and intercalated ducts of the pancreas. It also stimulates bile production by the liver; the bile emulsifies dietary fats in the duodenum so that pancreatic lipase can act upon them. Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin, is stimulating the gallbladder to contract, delivering its stored bile for the same reason.
3.Prosecretin is a precursor to secretin, which is present in digestion. Secretin is stored in this unusable form, and is activated by gastric acid in the lower intestine to neutralize the pH and ensure no damage is done to the small intestine by the aforementioned acid.
4.In 2007, secretin was discovered to play a role in osmoregulation by acting on the hypothalamus, pituitary gland, and kidney.
Specification of Secretin
Secretin Acetate, also called secretin, has recently been in the brain and purified, therefore also joined the ranks of brain gut peptide. Role in stimulating the pancreas to secrete large amounts of bicarbonate rich pancreatic juice, to produce maximal stimulation of secretin dose on human, dog, pig, as an intravenous injection or intravenous infusion per kg per hour 1 clinical units, the equivalent of 200 to 250 ng, strengthen weak effect on pancreatic enzyme secretion, but as with Pro pancreozymin given together, increased pancreozymin secretion, has inhibitory effect on human, dog, rat gastric acid secretion and gastrointestinal activity. Exogenous secretin, with a half-life of 4.1 minutes, metabolic clearance rate of 15 ml / min / kg body weight.
More recent research has determined that this chemical may play a role in osmoregulation by helping to manage the kidneys pituitary and hypothalamus.
Products list of Peptide:
|Products Name||Products CAS|
|Thymosin α1 Acetate||62304-98-7|
|Thymosin β4 Acetate||77591-33-4|
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