Tetracaine HCl
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Tetracaine hydrochloride Basic information
Product Name: | Tetracaine hydrochloride |
CAS: | 136-47-0 |
MF: | C15H25ClN2O2 |
MW: | 300.82 |
EINECS: | 205-248-5 |
Product Categories: | API intermediates;Sodium channel;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;PONTOCAINE;Local anesthetic |
Mol File: | 136-47-0.mol |
Tetracaine HCl Description:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification
is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine hcl Usage:
1) Tetracaine Hcl For block anesthesia and epidural anesthesia.
2) Tetracaine Hcl used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime
poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
3) Tetracaine Hcl As painkillers of injection in the medicament.
4) Tetracaine Hcl used in
suppository and ointment preparation,
5) Tetracaine Hcl has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the Function of calcium release channels (ryanodine receptors) that control
the release of calcium from
Intracellular stores.
6) Tetracaine is an allosteric blocker of channel function.At low concentrations, Tetracaine causes an initial inhibition of spontaneous calcium release events, while
at high Concentrations, tetracaine blocks release completely.
COA:
Test Items | Specification | Test Results |
Appearance | Fine, white, crystalline, odorless powder | confirm |
Identification | ABC in Pass | confirm |
Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene | confirm |
USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. | confirm |
Melting point | 145~150 degree | 146.0~147.5 |
Chromatographic purity | In Pass | confirm |
Related substance | Not more than the reference solution 0.05% | confirm |
Heavy metals | ≤10ppm | confirm |
PH | 4.5-6.5 | 5.8 |
Residue on ignition | ≤0.10% | 0.05% |
Loss on Drying | ≤ 0.5% | 0.19% |
Assay | 98.0 -101.0% | 100.1% |
Conclusion | Confirms USP 32 | |
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