Tetracaine HCl

Tetracaine HCl

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details


Tetracaine HCl



 Contact : Mr.Thyen   

 Email us at zhangyinglong@ycphar.com   

 Whatsapp : +86 180 3817 6818

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Tetracaine hydrochloride Basic information

Product Name:

Tetracaine hydrochloride

CAS:

136-47-0

MF:

C15H25ClN2O2

MW:

300.82

EINECS:

205-248-5

Product Categories:

API intermediates;Sodium channel;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical    intermediate;PONTOCAINE;Local anesthetic

Mol File:

136-47-0.mol


Tetracaine HCl Description:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

 

Tetracaine hcl Usage:
1) Tetracaine Hcl For block anesthesia and epidural anesthesia.
2) Tetracaine Hcl used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
3) Tetracaine Hcl As painkillers of injection in the medicament.
4) Tetracaine Hcl used in suppository and ointment preparation,
5) Tetracaine Hcl has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the Function of calcium release channels (ryanodine receptors) that control the release of calcium from
Intracellular stores.
6) Tetracaine is an allosteric blocker of channel function.At low concentrations, Tetracaine causes an initial inhibition of spontaneous calcium release events, while at high Concentrations, tetracaine blocks release completely.

 

COA:

Test Items

Specification

Test Results

Appearance

Fine, white, crystalline, odorless powder

confirm

Identification

ABC in Pass

confirm

Solubility

Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene

confirm

USP Reference standards

USP Tetracaine Hydrochloride RS. USP Endotoxin RS.

confirm

Melting point

145~150 degree

146.0~147.5
     degree

Chromatographic purity

In Pass

confirm

Related substance

Not more than the reference solution 0.05%

confirm

Heavy metals

≤10ppm

confirm

PH

4.5-6.5

5.8

Residue on ignition

≤0.10%

0.05%

Loss on Drying

≤ 0.5%

0.19%

Assay

98.0 -101.0%

100.1%

Conclusion

Confirms USP 32


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