Pharmaceutical Intermediates;Aliphatics;Organic acids;Amino Acids;Food Additives;pharm raw material;food additives;Nutrition
Mol File:
328-50-7.mol
2-Ketoglutaric acid Chemical Properties
Melting point
113-115 °C
FEMA
3891
storage temp.
2-8°C
solubility
H2O: soluble0.1g/mL, clear, colorless
form
Crystalline Powder
pka
2.47(at 25ºC)
color
White to slightly yellow
Water Solubility
Soluble in water, methanol and dimethyl sulfoxide.
Merck
14,5303
BRN
1705689
CAS DataBase Reference
328-50-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Oxopentanedioic acid(328-50-7)
EPA Substance Registry System
Pentanedioic acid, 2-oxo-(328-50-7)
Safety Information
Hazard Codes
Xi,T
Risk Statements
37/38-41-36/37/38-23/24/25
Safety Statements
26-39-45-36/37/39
WGK Germany
3
TSCA
Yes
HS Code
29183000
MSDS Information
Provider
Language
alpha-Ketoglutaric acid
English
SigmaAldrich
English
ACROS
English
ALFA
English
2-Ketoglutaric acid Usage And Synthesis
Description
2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body's nitrogen chemistry and prevent nitrogen excess in body tissues and fluids. α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.
Chemical Properties
Crystalline
Uses
A derivative of glutaric acid.
Definition
ChEBI: An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.
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