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Chemical name: Agomelatine
CAS registry number: 138112-76-2
Chemical Formula: C15-H17-N-O2
Molecular Weight: 243
Therapeutic Category: Antidepressant: Melatonin receptor agonist
Chemical Names: N-[2-(7-metoxy-1-naphtyl)etyl]acetamide (WHO),N-[2-(7-Metoxynaphtalen-1-yl)etyl]acetamide (BAN)
Appearance: White powder
Drug class: Atypical antidepressant drug
Items of analysis
White or off white powder
Loss on dry
What is Agomelatine?
Do you think agomelatine is a solid antidepressant? How do you think it compares to other more typical antidepressants like Prozac?
Agomelatine's unique pharmacology and favorable side effect profile make it a boon for depressed patients, especially those who have not responded to conventional antidepressants.
How does it work?
Valdoxan tablets contain the active ingredient agomelatine, which is a type of medicine called an antidepressant. It is used to treat depression.
Agomelatine acts on the melatonin and serotonin receptors in the brain.
Melatonin is a hormone made by the pineal gland, a structure in the brain. It is normally released soon after it starts to get dark. The amount produced then increases until about four am, before dropping off again. Melatonin is linked with the control of circadian rhythms and promoting sleep. It works by acting on melatonin receptors in the brain.
Agomelatine mimics the action of melatonin and helps to re-synchronise the body’s circadian rhythms. These include mood, anxiety, appetite, body temperature and sleep/wake cycles. These circadian rhythms, particularly sleep cycles, are severely disturbed in people with depression. Agomelatine’s main action is to improve the onset and quality of sleep and this in turn has an antidepressant effect.
Agomelatine also helps to improve mood in depression by increasing noradrenaline and dopamine release in the brain. These are natural chemicals called neurotransmitters that are involved, amongst other things, in regulating mood.
Before taking agomelatine:
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking agomelatine it is important that your doctor knows:
If you are under 18 or over 75 years of age.
If you are pregnant or breast-feeding.
If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
If you have ever had abnormally 'high' moods or dementia.
If you are taking any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.