Cyclosporin Raw Material For Anti-Allogeneic

Cyclosporin Raw Material For Anti-Allogeneic

Contact : Miss.fueng--------------------------------- Email us at sue@yccreate.com--------------------- Whatsapp : +86 189 6116 7067

Product Details

Cyclosporin

 

Contact : Miss.Fueng 

Email us at sue@yccreate.com  

Whatsapp : +86 189 6116 7067 

 

Product Name: Cyclosporin A,Cyclosporin A Powder
CAS: 59865-13-3
MF: C62H111N11O12
MW: 1202.61
Chemical Properties:White Crystalline Powder
Assay: 99.5%

What is Cyclosporin A?
Cyclosporine or cyclosporine A, is an immunosuppressant drug. Cyclosporine widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Cyclosporine has been studied in transplants of skin, heart, kidney, liver, lung, pancreas, bone marrow, and small intestine. Cyclosporine initially isolated from the fungus Tolypocladium inflatum isolated from a soil, ciclosporine is a cyclicnonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.

Cyclosporin A Application
Cyclosporine is thought to bind to the cytosolic protein cyclophilin(immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (nuclear factor of activated T-cells), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines.   Ciclosporin prevents the dephosphorlyation of NF-AT by binding to cyclophilin.[7] It also inhibits lymphokine production andinterleukin release and, therefore, leads to a reduced function of effector T-cells. It does not affect cytostaticactivity.

Cyclosporine also has an effect on mitochondria. Ciclosporine prevents the mitochondrial permeability transition pore from opening, thus inhibiting cytochrome c release, a potent apoptotic stimulation factor. However, this is not the primary mechanism of action for clinical use, but rather an important effect for research on apoptosis.

Cyclosporin A Specification

Items of analysis

Specification

Results

Description

a white to off-white powder

white powder

By IR spectroscopy

IR spectrum of sample should match with standard IR spectrum

conforms

by HPLC

the retention time of the major peak of the sample solution corresponds to that of the standard solution as obtained in the assay

coforms

loss on drying

not more than 4.0%

2.2%

residue on ignition

not more than 0.2%

0.04%

heavy metals

not more than 20ppm

less than 20ppm

specific optical rotaion

-80 °  to -90 °

-89 °

any individual impurity

not more than 0.5%

0.08%

total impurity

not more than 1.0%

0.25%

assay by HPLC

98.0%-102.0%

99.0%

 

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