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Glycopyrronium bromide is a medication of the muscarinic anticholinergic group. It does not cross the blood-brain barrier and consequently has no to few central effects. It is available in by mouth, intravenous, and inhalated forms.
It is a synthetic quaternary amine. The cation, which is the active moiety, is called glycopyrronium (INN) or glycopyrrolate (USAN).
In June 2018, glycopyrronium was approved by the FDA to treat excessive underarm sweating becoming the first drug developed specifically to reduce excessive sweating.
1.In anesthesia, glycopyrronium injection can be used as a before surgery in order to reduce salivary, tracheobronchial, and pharyngeal secretions, as well as decreasing the acidity of gastric secretion. It is also used in conjunction with neostigmine, a neuromuscular blocking reversal agent, to prevent neostigmine's muscarinic effects such as bradycardia.
2.It is also used to reduce excessive saliva (sialorrhea), and Ménière's disease.
3.It decreases acid secretion in the stomach and so may be used for treating stomach ulcers, in combination with other medications.
4.It has been used topically and orally to treat hyperhidrosis, in particular, gustatory hyperhidrosis.
5.In inhalable form it is used to treat chronic obstructive pulmonary disease (COPD). Doses for inhalation are much lower than oral ones, so that swallowing a dose will not have an effect.
Product name Glycopyrronium bromide
Description White crystalline powder
Assay( on dried basis) 98.0%～101.0%
Type Antispasmodic, API
Melting point: 192-195°C
Molecular Weight 398.341 g/mol
Total impurities not more than 0.5%
Methanol not more than 0.3%
Butanone not more than 0.5%
Ethyl acetate not more than 0.5%
Loss on drying Not more than 0.5%
Residue on ignition Not more than 0.1%
Heavy metals Not more than 10ppm
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Keywords: Glycopyrronium bromide,CAS 51186-83-5Pharmaceutical, drug,API, used as an antispasmodic; in some disorders of the gastrointestinal tract; to reduce salivation with some anesthetics.
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