Product name: 17A-hydroxyprogesterone Synonyms: 17A-hydroxyprogesterone CAS No.: 68-96-2 EINEC No.: 200-699-4 Packaging: 1kg/bag Assay: 99% Molecular Formula: C21H30O3 Molecular weight: 330.4611 Density: 1.15g/cm3 Melting point: 276 ºC Boiling point: 482.9 ° C at 760 mmHg Flash point: 259.9 ° C Steam pressure: 2.37E-11mmHg at 25 ° C Appearance: White or white crystalline powder
What is 17α-Hydroxyprogesterone?
17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesisof othersteroid hormones, including the corticosteroids and the androgens and the estrogens.
It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3β-hydroxysteroid dehydrogenase isomerase.
17-OHP increases in the third trimester of pregnancy primarily due to fetal adrenal production. This steroid is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children, and in women, 20-100 ng/dl prior to ovulation, and 100-500 ng/dl during theluteal phase.
Hydroxyprogesterone is a form of progestin, a manmade form of a female hormone called progesterone. Hydroxyprogesterone is used to lower the risk of premature birth in a woman who has already had one premature baby. This medication will not stop premature labor that has already begun. Hydroxyprogesterone is not for use in women who have had more than one pregnancy. Hydroxyprogesterone may also be used for purposes not listed in this medication guide.
Reducing the risk of delivering a baby too early (preterm birth). Hydroxyprogesterone should only be used by women who are pregnant with one baby and have had a preterm delivery of one baby in the past.
Hydroxyprogesterone is a synthetic hormone (progestin). How it works to reduce the risk of recurrent preterm birth is not known.
This medication is used in women who are pregnant with a single baby, and who have delivered a baby too early (preterm) in the past. It is used to help lower the risk of having a preterm baby again. Hydroxyprogesterone is a man-made form of a female hormone (progestin). It is not known how it works to prevent preterm births.
This medication is not intended to prevent preterm birth in women pregnant with more than one baby (such as twins, triplets). It is also not intended to stop active preterm labor.
17a-Hydroxyprogesterone Caproate Specifications:
White or almost white crystalline powder, odorless
insoluble in water, solube in ether, slightly soluble in benzene
Specific Optical Rotation
+58°---+64° (1% chloroform Solution)
about 120 -124 ºC
Free N-Caproic Acid
Methanol ≤ 3000PPM
Dichloromethane ≤ 600PPM
Conforms to USP31
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