CAS 68-96-2 17A-Hydroxyprogesterone

CAS 68-96-2 17A-Hydroxyprogesterone

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CAS 68-96-2 17A-Hydroxyprogesterone

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Product name: 17A-hydroxyprogesterone 
Synonyms: 17A-hydroxyprogesterone
CAS No.: 68-96-2
EINEC No.: 200-699-4
Packaging: 1kg/bag
Assay: 99%
Molecular Formula: C21H30O3
Molecular weight: 330.4611
Density: 1.15g/cm3
Melting point: 276 ºC
Boiling point: 482.9 ° C at 760 mmHg
Flash point: 259.9 ° C
Steam pressure: 2.37E-11mmHg at 25 ° C
Appearance: White or white crystalline powder

What is 17α-Hydroxyprogesterone?

17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesisof othersteroid hormones, including the corticosteroids and the androgens and the estrogens.

It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3β-hydroxysteroid dehydrogenase isomerase.

17-OHP increases in the third trimester of pregnancy primarily due to fetal adrenal production.
This steroid is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children, and in women, 20-100 ng/dl prior to ovulation, and 100-500 ng/dl during theluteal phase.

Hydroxyprogesterone is a form of progestin, a manmade form of a female hormone called progesterone.
Hydroxyprogesterone is used to lower the risk of premature birth in a woman who has already had one premature baby. This medication will not stop premature labor that has already begun.
Hydroxyprogesterone is not for use in women who have had more than one pregnancy.
Hydroxyprogesterone may also be used for purposes not listed in this medication guide.

17-Hydroxyprogesterone Application:

Reducing the risk of delivering a baby too early (preterm birth). Hydroxyprogesterone should only be used by women who are pregnant with one baby and have had a preterm delivery of one baby in the past.

Hydroxyprogesterone is a synthetic hormone (progestin). How it works to reduce the risk of recurrent preterm birth is not known.

17-Hydroxyprogesterone Uses:

This medication is used in women who are pregnant with a single baby, and who have delivered a baby too early (preterm) in the past. It is used to help lower the risk of having a preterm baby again. Hydroxyprogesterone is a man-made form of a female hormone (progestin). It is not known how it works to prevent preterm births.

This medication is not intended to prevent preterm birth in women pregnant with more than one baby (such as twins, triplets). It is also not intended to stop active preterm labor.

17a-Hydroxyprogesterone Caproate Specifications:

DescriptionWhite or almost white crystalline powder, odorlessConforms
Solubilityinsoluble in water, solube in ether, slightly soluble in benzeneConforms
Specific Optical Rotation +58°---+64° (1% chloroform Solution) 60.3°
Melting Pointabout 120  -124 ºC123ºC
Water ≤0.1%0.05%
Free N-Caproic Acid ≤0.58%0.20%
Ordinary Impurities ≤2.0%conforms
Residual SolventsMethanol ≤ 3000PPM1280PPM
Dichloromethane ≤ 600PPM80PPM
ConclusionConforms to USP31

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