Cimetidine CAS 51481-61-9

Cimetidine CAS 51481-61-9

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Cimetidine CAS 51481-61-9

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Product Name:Cimetidine
Product Categories:Active Pharmaceutical Ingredients;Heterocycles;API intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;MAXIPIME;Other APIs;API
Mol File:51481-61-9.mol

Cimetidine Chemical Properties
Melting point 139-144°C
storage temp. 2-8°C
Water Solubility 0.5 g/100 mL at 20 ºC
Merck 2279
CAS DataBase Reference51481-61-9(CAS DataBase Reference)
NIST Chemistry ReferenceCimetidine(51481-61-9)
EPA Substance Registry SystemGuanidine, N-cyano-N'-methyl-N''-[ 2-[[(5-methyl-1H-imidazol- 4-yl)methyl]thio]ethyl]-(51481-61-9)
Hazard Codes T,Xn
Risk Statements 60-42/43-36/37/38-20/22
Safety Statements 53-26-36/37/39-45-36-22
WGK Germany 3
RTECS MF0035500
Hazardous Substances Data51481-61-9(Hazardous Substances Data)

MSDS Information

Cimetidine Usage And Synthesis
DescriptionCimetidine (brand name: Tagamet) is a kind of histamine H2 receptor antagonist being capable of inhibiting the production of stomach acid, which reduces the gastric volume and acidity. It is mainly used for the treatment of heartburn and peptic ulcers. There are also evidences that it can be used for the treatment of common warts, chronic calcific tendinitis of the shoulder, and even colorectal cancer. It is capable of not only inhibiting the gastric acid secretion, as well as pepsin and gastrins output, but also inhibiting the activity of cytochrome P450. It reduces the gastric acid secretion through binding to the H2 receptor locating on the basolateral membrane of the gastric parietal cell, and further blocking histamine effect.
Chemical PropertiesWhite Solid
UsesCompetitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output
DefinitionChEBI: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H -receptor antagonist that inhibits the production of acid in stomach.
General DescriptionWhite crystals with a slight sulfur-mercaptan odor.
Air & Water ReactionsSlightly water soluble.
Fire HazardFlash point data for Cimetidine are not available. Cimetidine is probably combustible.
Biological ActivityWidely used H 2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I 1 imidazoline binding site ligand.

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