Clobetasol propionate
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MF:C25H32ClFO5
MW:466.97
CAS:25122-46-7
Appearance:white powder
Purity:99%
Standard:USP standard
Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.
The COA of Clobetasol propionate:
Product name | Clobetasol propionate | ||
CAS No. | 25122-46-7 | Outer Packing | 1KG/bag |
Production date | May.,05, 2018 | Shelf life | May.,04, 2021 |
Standard adopted | USP38 | ||
Items of analysis | Specification | Results | |
Description | White or almost white crystalline powder | Almost white crystalline powder | |
Solubility | Practically insoluble in water,slightly soluble in benzene and diethyl ether ,sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane | Complies | |
Identification (IR) | Complies with the Standard | Complies | |
Specific Rotation | +98°～+104° | +102.6° | |
Melting point | about 196℃ | 193.0℃～195.0℃ | |
Loss on drying | max.2.0% | 0.06% | |
Residue on ignition | max. 0.1% | 0.03% | |
Heavy Metals | max.20ppm | Complies | |
Single impurity | N.m.t 1.0% | 0.14% | |
Sum impurity | N.m.t 2.5% | 0.49% | |
Organic volatile impurities | meet the ICH requirement | Complies | |
Assay(HPLC,basisondrying) | 98.5%～102.0% | 99.5% | |
THF | Not more than 720ppm | Complies | |
Methanol | Not more than 3000ppm | Complies | |
DMF | Not more than 880ppm | Complies | |
Pyridine | ≤ 200ppm Not more than 200ppm | Complies | |
Dichloromethane | Not more than 600ppm | Complies | |
Ethanol | Not more than 5000ppm | Complies | |
Acetone | Not more than 5000ppm | Complies | |
Conclusion | Qualified | ||
