Clobetasol Propionate

Clobetasol Propionate

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details


Clobetasol propionate


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


MF:C25H32ClFO5
MW:466.97
CAS:25122-46-7
Appearance:white powder
Purity:99%
Standard:USP standard

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak.


Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.

The COA of Clobetasol propionate:

Product name

Clobetasol propionate

CAS No.

25122-46-7

Outer Packing

1KG/bag

Standard adopted

USP38

Items of analysis

Specification

Results

Description

White or almost white crystalline powder

Almost white crystalline powder

Solubility

Practically insoluble in water,slightly soluble in benzene and diethyl ether ,sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane

Complies

Identification (IR)

Complies with the Standard

Complies

Specific Rotation

+98°~+104°

+102.6°

Melting point

about 196℃

193.0℃~195.0℃

Loss on drying

max.2.0%

0.06%

Residue on ignition

max. 0.1%

0.03%

Heavy Metals

max.20ppm

Complies

Single impurity

N.m.t 1.0%

0.14%

Sum impurity

N.m.t 2.5%

0.49%

Organic volatile impurities

meet the ICH requirement

Complies

Assay(HPLC,basisondrying)

98.5%~102.0%

99.5%

THF

Not more than 720ppm

Complies

Methanol

Not more than 3000ppm

Complies

DMF

Not more than 880ppm

Complies


Pyridine

≤ 200ppm

Not more than 200ppm

Complies

Dichloromethane

Not more than 600ppm

Complies

Ethanol

Not more than 5000ppm

Complies

Acetone

Not more than 5000ppm

Complies

Conclusion

Qualified

Inquiry