Clorsulon CAS 60200-06-8

Clorsulon CAS 60200-06-8

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Clorsulon CAS 60200-06-8

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Clorsulon CAS 60200-06-8 for Veterinary Medicine

Other name: 4-Amino-6-(trichlorovinyl)-1, 3-benzenedisulfonamide
CAS NO.: 60200-06-8
EINECS NO.: 262-100-2
MF: C8H8Cl3N3O4S2
MW: 380.65
Assay: 98.5%min
Appearance: White crystalline powder
Loss on drying: ≤ 5.0%
Residue on ignition: ≤ 1.0%
Heavy metal: ≤ 20ppm
As: ≤ 5ppm
Total plate count: ≤ 1000cfu/g
Yeast & mould: ≤ 100cfu/g
E. Coli: Not detected
Uses: It is antichistosomal

Clorsulon is approved for use in the treatment of immature and adult forms of Fasciola hepatica(Liver fluke) in cattle. It is not effective against immature flukes less than 8 weeks old. It also has activity against Fasciola gigantica.
Although not approved, the drug has been used in practice in various other species (e.g., sheep, llamas). It has activity against F. magna in sheep, but is not completely effective in eradicating the organism after a single dose, thereby severely limiting its clinical usefulness against this parasite. Clorsulon is also not effective against the rumen fluke (Paramphistomum).

After oral administration to cattle, the drug is absorbed rapidly with peak levels occurring in about 4 hours. Approximately 75% of the circulating drug is found in the plasma and 25% in erythrocytes. At 8-12 hours after administration, clorsulon levels peak in the fluke.
Contraindications/Precautions/Reproductive Safety
No milk withdrawal time has been determined, and the drug is labeled not to be used in female dairy cattle of breeding age. Clorsulon is considered to be safe to use in pregnant or breeding animals.


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