Cyclosporin CAS 59865-13-3

Cyclosporin CAS 59865-13-3

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Product Details

Cyclosporin CAS 59865-13-3

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Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.1,2,3 It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT.1,4,5 Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.

Basic information:

Chemical name:     Cyclosporin A

Alternative Name: CsA
Formula: C62H111N11O12
MW: 1202.6
Source:    Isolated from Fusarium solani
CAS: 59865-13-3
Purity: ≥98% (Assay)
Appearance: White to off-white powder.
Solubility: Soluble in  DMSO (25mg/ml), methanol, 100% ethanol (25mg/ml), acetone or petroleum ether; insoluble in water.
Shipping: Ambient
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.



CAS No.79217-60-0;59865-13-3Outer Packing
Production date2017.11.09Shelf life
Standard adoptedUSP36
Items of analysisSpecificationResults
AppearanceWhite crystalline powderWhite crystalline powder
SolubilityTo complyComplies
IdentificationTo complyComplies
Loss on drying2.0% max0.4%
Heavy metals0.002% max<0.002%
individual impurity0.7% max0.39%
sum of all impurity1.5% max
Any other impurity0.1% max0.07%
Acetone0.5% max0.29%
Ethanol0.5% max0.01%
Ethyl acetate0.5% max0.02%

Medical uses:

Ciclosporin is approved by the FDA to treat and prevent graft-versus-host disease in bone marrow transplantation and to prevent rejection of kidney, heart, and liver transplants.It is also approved in the US for treating of rheumatoid arthritis and psoriasis, persistent nummular keratitis following adenoviral keratoconjunctivitis,and as eye drops for treating dry eyes caused by Sjögren's syndrome and meibomian gland dysfunction.

In addition to these indications, ciclosporin is also used in severe atopic dermatitis, Kimura disease, pyoderma gangrenosum, chronic hives, acute systemic mastocytosis, and posterior or intermediate uveitis with noninfective cause.It is also used, albeit infrequently, in severe rheumatoid arthritis and related diseases.

Ciclosporin has also been used in people with acute severe ulcerative colitis and hives that do not respond to treatment with steroids.

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