Domperidone CAS 57808-66-9

Domperidone CAS 57808-66-9

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Product Details

Domperidone CAS 57808-66-9

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Basic Information:

Chemical name: Domperidone
MF: C22H24ClN5O2
MW: 425.91
CAS: 57808-66-9
Appearance: White powder
Package: 25kg/Drum



Product nameDomperidone BP
Outer Packing25KG/DRUM
Production date
Shelf life
Standard adoptedBP
Items of analysisSpecificationResults
Appearancewhite or almost white powderwhite powder
solubilitypractically insoluble in water,soluble in dimethyl formanide,slightly soluble in ethanol(96%) and in methanol.complies
A.melting point244.0 ºC-248.0ºC246.0 ºC-247.1ºC IRIR spectrum of test sample should match with IR spectrum of working standard.complies TLCthe principal spot in the chromatogram obtained with the test solution in similar in position and size to the principal spot in the chromatogram obtained with reference solution(a).complies
appearance of solution

the solution should be clear and not more intensely colored than reference solution Y6
Meets the requirement
Impurity -ANot more than 0.25%0.09%
Impurity-BNot more than 0.25%Not detected
Impurity-CNot more than 0.25%Not detected
Impurity-DNot more than 0.25%0.12%
Impurity-ENot more than 0.25%Not detected
Impurity-FNot more than 0.25%Not detected
Unspicified impuritiesNot more than 0.10%0.07%

total impurities

Not more than 0.5%

heavy metalsNot more than 20ppmless than 20 ppm
loss on dryingNot more than 0.5%0.43%
sulphate ashNot more than 0.1%0.04%
assay on chemical(on dried basis)99.0%-101.0% w/w99.7% w/w
particl size(malvern particle size analyzer)d90-not less than 400;d50-not later than 300meets the requirement


Domperidone, sold under the brand name Motilium among others, is a peripherally selective dopamine D2 receptor antagonist that was developed by Janssen Pharmaceutica and is used as an antiemetic, gastroprokinetic agent, and galactagogue.It may be administered orally or rectally, and is available in the form of tablets, orally disintegrating tablets (based on Zydis technology),suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.

Medical uses:

It was reported in 2007 that domperidone is available in 58 countries, including Canada,but the uses or indications of domperidone vary between nations. In Italy it is used in the treatment of gastroesophageal reflux disease and in Canada, the drug is indicated in upper gastrointestinal motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents. In the United Kingdom, domperidone is only indicated for the treatment of nausea and vomiting and the treatment duration is usually limited to 1 week.

In the United States, domperidone is not currently a legally marketed human drug and it is not approved for sale in the U.S. On 7 June 2004, FDA issued a public warning that distributing any domperidone-containing products is illegal.

Nausea and vomiting:

There is some evidence that domperidone has antiemetic activity.It is recommended in the Canadian Headache Society's guidelines for treatment of nausea associated with acute migraine.


Gastroparesis is a medical condition characterised by delayed emptying of the stomach when there is no mechanical gastric outlet obstruction. Its cause is most commonly idiopathic, a diabetic complication or a result of abdominal surgery. The condition causes nausea, vomiting, fullness after eating, early satiety (feeling full before the meal is finished), abdominal pain and bloating.

Domperidone may be useful in diabetic and idiopathic gastroparesis.

However, increased rate of gastric emptying induced by drugs like domperidone does not always correlate (equate) well with relief of symptoms.

How does this medication work?

Domperidone belongs to the group of medications called dopamine antagonists. It is used to treat slowed movement in the gastrointestinal tract associated with diabetes and gastritis (inflammation of the stomach lining). For these people, domperidone improves symptoms of nausea, vomiting, bloating, and feeling of fullness.

Domperidone is also used to prevent stomach problems such as nausea and vomiting associated with certain medications used to treat Parkinson's disease. It works to improve symptoms by helping the stomach to empty more quickly and to reduce nausea.


As far as payment methods are considered, we accept a number of secure payment methods, customers can pay to us through any of the payment methods mentioned below:-

Western Union: Western Union Money Transfer, a very famous and secure money transfer method is accepted by us. Our customer who desire to pay us through this method can transfer payment to us by using WU. To pay us through WU, after placing your order, go to your nearest WU franchise, make the payment there and confirm us the MTCN. After receiving the payment we will process your order.

Money Gram: We also accept Money Gram, to pay us through Money Gram, after placing your order please contact us to get the payment sending details. After that, go to your nearest Money Gram franchise, make your payment and confirm us the Reference  Number provided by the money gram at the above email address.

We accept payments via Western Union or Money Gram only. We don’t accept PayPal anymore, that we were doing in past but now we are not able to use PayPal anymore.(Some of the products we deals in are highly banned, so credit card and bank wire will not be the safe & secure for both of buyer and seller. For these type of orders, Western Union and Money Gram are most safe and secure payment methods).

Bit Coins: Bit Coins are also accepted by us, if you want to pay us through Bit Coins, please contact us, we will send you our Bit Coin address, you will send us payment at that address and we will ship your order.

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