CAS number: 136434-34-9 Molecular Formula: C18H19NOS·HCl Molecular weight: 333.88 Appearance: white or almost white crystalline powder Solubility: Slightly soluble in water, easily soluble in methanol, almost insoluble in n-hexane Loss on drying: ≤0.5% Sulphated Ash: ≤0.1% Heavy metal: ≤20ppm Specific rotation: +118~+123o Content (HPLC): ≥99.0% Single impurity: ≤ 0.1 Chiral isomer: ≤ 0.5% The main purpose: antidepressants
Use Duloxetine hydrochloride/Cymbaha (hereinafter referred to as duloxetine) is a 5-hydroxytryptamine and norepinephrine reuptake inhibitor developed by Eli Lilly. 5 Both serotonin and norepinephrine are central neurotransmitters and play an important role in regulating emotion and sensitivity to pain. Duloxetine can inhibit the reuptake of neurons to serotonin and norepinephrine, thereby increasing the concentration of these two central neurotransmitters in the brain and spinal cord. It can be used to treat certain mood disorders such as depression. And anxiety disorders and relieve central pain such as diabetic peripheral neuropathy pain and fibromyalgia in women. Duloxetine can also act on the 5-hydroxytryptamine and norepinephrine receptors in the urethra, thereby enhancing the neurological tone and contractility of the urinary sphincter, and is therefore effective in the treatment of stress urinary incontinence in women. Duloxetine is an oral enteric-coated capsule preparation. It was first approved in the United States in August 2004 and has now been marketed in more than 70 countries. The global sales of duloxetine exceeded US$1.3 billion in 2006, and its sales in 2007 and 2008 increased significantly to US$2.1 billion and US$2.7 billion, respectively, making it one of the fastest-growing drugs in the world in recent years. .
Application In August and December 2004, the United States and the European Union approved duloxetine for the treatment of major adult depression. This is the first indication that duloxetine is officially approved for clinical use. A total of 512 subjects randomized, double-blind, placebo-controlled, pivotal study j1 showed that duloxetine was significantly lower than placebo at 17 weeks with 60 nag once-daily nausea. The total score of the table (tlDRS-17), and significantly improved depressive symptoms after 1 wk of treatment. Another study of 478 patients with severe depression in China, South Korea, and other countries confirmed that the efficacy of duloxetine 60 mg once a day to relieve depressive symptoms is at least comparable to the most commonly used selective serotonin reuptake One paroxetine/Paxii 20 mg/d was inhibited with fewer side effects (smaller) and did not cause weight gain and sexual dysfunction in the patient. In addition, duloxetine can also significantly improve physical symptoms in patients with depression, including insomnia, bradykinesia, pain, and headaches, which are usually those that cannot be achieved with the use of serotonin reuptake inhibitors. Duloxetine is expected to replace the serotonin reuptake inhibitor as a first-line choice for the treatment of major depression.
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