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Product Name | Estradiol Benzoate |
Synonyms | beta-Estradiol-3-benzoate; Oestradiol Benzoate; 17beta-Estradiol benzoate; 1,3,5(10)-Estratriene-3,17b-diol 3-benzoate; 3,17b-Dihydroxy-1,3,5(10)-estratriene 3-benzoate; (17beta)-Estra-1,3,5(10)-triene-3,17-diol 3-benzoate; |
Molecular Formula | C25H28O3 |
Molecular Weight | 376.488 |
InChI | InChI=1/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1 |
CAS Registry Number | 50-50-0 |
EINECS | 200-043-7 |
Molecular Structure | |
Density | 1.185g/cm3 |
Melting point | 191-198C |
Boiling point | 531.2°C at 760 mmHg |
Refractive index | 1.604 |
Flash point | 212C |
Vapour Pressure | 4.08E-12mmHg at 25C |
Assay | 99% |
Appearance | White or light yellow crystalline powder |
The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.
Application
The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food
and ethanol consumption were studied in ovarectomized rats given free access to food, a 10% ethanol solution, and water. EB led to an immediate, but transient, suppression of both food and ethanol intake. The time course and
magnitude of these effects were virtually identical.
While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethanol consumption apparently
resulted from decreased rates of licking within bouts. Gradual increases in the frequency of eating and ethanol-drinking bouts allowed total food and ethanol intake to return to baseline within three weeks of the first injection.
Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethanol intake were discussed in terms of ethanol's caloric property.
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