Gefitinib CAS 184475-35-2

Gefitinib CAS 184475-35-2

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details

Gefitinib CAS 184475-35-2

Contacting Information :

Contact person : Thyen

Skype :live:simeiquan-zhang

WhatsApp : +8618038176818

E-mail : zhangyinglong@ycphar.com

Website : www.sellsteroid.com


Technical Data:

M. Wt: 446.9
Formula: C22H24ClFN4O3
Storage: Store at RT
Purity: ≥98% (HPLC)
CAS Number: 184475-35-2
PubChem ID: 123631
InChI Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N
Solubility: DMSO (44.69), ethanol (4.47)

COA:
 

Product name 
Gefitinib
 
CAS No. 
184475-35-2
Outer Packing 
1KG
 
Production date 
May,05,2016
Shelf life 
May.04,2019
Standard adopted 
 
house standard
Items of analysisSpecificationResults
 
 
Appearance
 
 
White to off-white powder
 
 
off-White powder
 
 
Identifcation
 
 
HPLC(RT)
 
 
Complies
 
 
Loss on drying
 
 
≤ 0.5%
 
 
0.13%
 
 
Residue on ignition
 
 
≤0.,1%
 
 
0.1%
 
 
Max Single Impurity
 
 
≤ 0.10 %
 
 
0.09%
 
 
Total Impurity
 
 
≤.1.0%
 
 
0.24%
 
 
Purity(HPLC)
 
 
≥99%
 
 
99.76%
ConclusionQualified



Mechanism of action:

Gefitinib is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB) which includes Her1(EGFR), Her2(erb-B2), Her3(erb-B3) and Her4 (Erb-B4). EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. This leads to inappropriate activation of the anti-apoptotic Ras signalling cascade, eventually leading to uncontrolled cell proliferation. Research on gefitinib-sensitive non-small cell lung cancers has shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways.These mutations tend to confer increased sensitivity to tyrosine kinase inhibitors such as gefitinib and erlotinib. Of the types of non-small cell lung cancer histologies, adenocarcinoma is the type that most often harbors these mutations. These mutations are more commonly seen in Asians, women, and non-smokers (who also tend to more often have adenocarcinoma).

Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.



Payments


As far as payment methods are considered, we accept a number of secure payment methods, customers can pay to us through any of the payment methods mentioned below:-


Western Union: Western Union Money Transfer, a very famous and secure money transfer method is accepted by us. Our customer who desire to pay us through this method can transfer payment to us by using WU. To pay us through WU, after placing your order, go to your nearest WU franchise, make the payment there and confirm us the MTCN. After receiving the payment we will process your order.


Money Gram: We also accept Money Gram, to pay us through Money Gram, after placing your order please contact us to get the payment sending details. After that, go to your nearest Money Gram franchise, make your payment and confirm us the Reference  Number provided by the money gram at the above email address.



We accept payments via Western Union or Money Gram only. We don’t accept PayPal anymore, that we were doing in past but now we are not able to use PayPal anymore.(Some of the products we deals in are highly banned, so credit card and bank wire will not be the safe & secure for both of buyer and seller. For these type of orders, Western Union and Money Gram are most safe and secure payment methods).



Bit Coins: Bit Coins are also accepted by us, if you want to pay us through Bit Coins, please contact us, we will send you our Bit Coin address, you will send us payment at that address and we will ship your order.

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