Gliclazide, chemical name is 1- (hexahydrocyclopenta [c] pyrrole -2 (1H) - yl) -3- (4-methylphenyl) sulfonyl urea, is the second generation of sulfur ureide oral hypoglycemic agents, and it also has dual function of hypoglycemic and improving blood clotting. It not only can improve the metabolism of diabetic patients, but also can improve or delay the occurrence of diabetic vascular complications. Gliclazide was developed by the French SERVIER company, and listed in France as early as 1972. Its trade names are diamicron gliclazide, methanesulfonic bicyclic urea to g pancreas, methanesulfonic grid urea, glick that sa. It is mainly used for the treatment of the onset of diet and exercise alone control ineffective of adulthood, and no ketosis tendency of light, moderate the type II diabetes. It also can improve diabetic retinopathy and metabolic disorders, vascular function. It can be used with biguanide oral hypoglycemic drugs, and used with insulin to treat insulin-dependent diabetes mellitus, in which condition that insulin dosage can be reduced. 1980s, it began to be supplied into the Chinese market. Now there has been more than 130 countries worldwide that registered and sold.
1. Hypoglycemic effect: gliclazide is the second-generation oral sulfonylurea hypoglycemic agents. Its role is more than ten times stronger than tolbutamide. Mechanism of action is to stimulate pancreatic β cells to release insulin, and then the high blood sugar drops. This may be because that sulfonylurea combines with β cell surface receptor, and increases the activation and simultaneously improves the sensitivity of outer periphery of the target tissue to insulin. 2. It can reduce platelet aggregation and adhesion, and prevent fibrin depositing in the microvasculature. 3. It can lower cholesterol savings, and reduce plasma concentrations of arterial triphosphate glycerides and fatty acids. The role of the three not only can treat diabetes metabolic disorders, but also prevent and treat complications like the development and progression of diabetes-blood vessels, retinal, renal disease.
The absorption of gliclazide is rapidly when it is taken orally. The plasma concentration peaks after two to six hours. Plasma protein binding rate is 94.2%. Τ1/2 is about 12 hours. Gliclazide is mainly used in the liver metabolism, and its metabolites has no hypoglycemic effect. 98% is excreted by kidney in less than 48 hours, and the content of unchanged drug in the urine is less than 5%.
Cyclopentane ortho anhydride as raw materials, ammoniates to obtain cyclopentane phthalimide. It reacts to obtain azabicyclo through catalytic reduction by catalysts like LiAlH4, KBH4/ZnCl2 or black platinum. And then azabicyclo reacts to give N-3-azabicyclo [3, 3, O] octane hydrochloride by nitrosation, zinc reduction. Finally it reacts with toluene sulfonylurea to obtain gliclazide through condensation.
Figure 1 The synthetic route of gliclazide
1. For adults with type 2 diabetes, diabetes associated with obesity or vascular lesions. 2. Hypoglycemic agents. It can be used for the treatment of non-insulin dependent diabetes mellitus. 3. Hypoglycemic agents, non-insulin dependent diabetes mellitus. The above information is edited by the Chemicalbook of Ge Qian.
Occasional mild nausea, vomiting, abdominal pain, constipation, diarrhea, erythema, urticaria, thrombocytopenia, neutropenia, anemia. Most adverse reactions disappeared after withdrawal.
1. Forbidden for patients allergic to gliclazide or sulfonylureas, sulfa drugs. 2. Forbidden for patients with type 1 diabetes. 3. Forbidden for patients with diabetic pre-coma, diabetic ketoacidosis. 4. Forbidden for patients with severe liver and kidney dysfunction. 5. Forbidden for leukopenia patients. 6. Forbidden for patients with stress situations like coma, severe burns, infection, trauma and major surgery. 7. Forbidden for patients with pregnant and lactating women
1. When patients with type 2 diabetes have infection, trauma, surgery, stress situations and ketoacidosis and hyperosmolar nonketotic diabetic coma, insulin therapy should be used instead. 2. When the overdose of gliclazide, eating too little or strenuous exercise, you should take attention to prevent hypoglycemia. 3. You must regularly check blood sugar, urine, and take eye examinations. 4. When gliclazide is combined with anticoagulants, you should have regular blood clotting check.
When gliclazide is used with nonsteroidal anti-inflammatory drug (especially salicylates), sulfa antibiotic, double coumarin anticoagulants, monoamine oxidase inhibitors, β-blockers, tetracycline, chloramphenicol, dicyclohexyl B piperidine, clofibrate, ethanol and other drugs, its dosage should be reduced to avoid hypoglycemia reaction.
White Cyrstalline Solid
antidiabetic, adhesion inhibitor
A sulfonylurea hypoglycemic agent. Used as an antidiabetic
Gliclazide Preparation Products And Raw materials
1, High quality with competitive price: 1)Standard: Enterprise Standard 2)All Purity≥99% 3)We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery 1)Parcel can be sent out in 24 hours after payment. Tracking number available. 2)Secure and discreet shipment. Various transportation methods for your choice. 3)Customs pass rate ≥99% 4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world. 1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Q1: Have your Product Quality been Approved by Third Party Lab? A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2:How do you treat quality complaint? A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem , caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order? A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount? A: Yes, for larger quantity, we always support with better price.
Q5:Do you accept VISA business credit card ? A:Sorry we don't accept VISA credit card, We'd like to accept bank transfer, Western Union or Paypal or Moneygram
Q6:How long does it take to the goods arrived ? A:It is Depending on your location, For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS. For mass order, please allow 5-8 days by Air, 20-35 days by Sea.
Q7. Do you have any reshipment policy ? we have good after-sale service and re-shipment policy if the parcel lose Our long association with our clients has brought great benefits We always take the upmost care in the packaging of our products our clients will confirm this as even they struggle to find them without help at times. But in spite of our best efforts it is still possible will seize a small number of packages. In this circumstance we promise reship free to establish long term relationship
Q8 :Can I get a sample? A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.
Hot Tags: gliclazide cas 21187-98-4, China, suppliers, manufacturers, wholesale, buy, price