English name: Guanosine Chemical formula: C10H13N5O5 CAS: 118-00-3 Molar mass: 283.24 Appearance: white or white crystalline powder. Melting point: 250 ° C (dec.) (Lit.) Specific rotation: -62 º (c = 3, in 0.1 N NaOH) Refractive index: -76 ° (C = 1, 1mol / L NaOH) Store at RT. Solubility: 0.1 M NaOH: 0.1 g / mL, clear, slightly yellow Water solubility: 0.75 g / L (25 ºC)
Guanine is a purine organic compounds, is a purine, carbon and nitrogen atoms from the composition of the characteristics of the double ring structure, and cytosine (cytosine) to three hydrogen bonds. In free or bound state in the guano, is one of five different nucleobases, and also exist in the deoxyribonucleic acid and RNA. The hydrochloride monohydrate dehydration at 100 ºC, 200 ºC loss of hydrogen chloride into guanine. Is one of the purine bases in nucleic acids. In DNA and RNA, can be obtained from the guano or fish scale hydrolysis can also be used 2,6,8 - trichloro purine and NaOH aqueous solution, NH3, HI reaction synthesis. In vivo, generally first synthesis of hypoxanthine nucleotide, the oxidation of xanthine nucleotide, and then by the amino generated guanine nucleotide, and from the guanine and its nucleoside synthesis of guanine nucleotide is only nuclear A Novel Remedy of Metabolism of. (3 ', 5'-cyclicguanylicacid, cGMP) was produced by guanylate cyclase. In vivo, its content is very small, but has important physiological functions, and cAMP on the metabolic regulation of antagonistic effect. CGMP also acts as a signaling messenger in the cell as a cAMP.
Industry is mainly used for the manufacture of acyclovir, trioxazole nucleoside, guanosine triphosphate and other drugs, the main raw material.
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