L-Carnitine Pharmaceutical Intermediates

L-Carnitine Pharmaceutical Intermediates

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details


L-Carnitine


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Product name:L-Carnitine,L(-)-Carnitine
CAS: 541-15-1
MF: C7H15NO3
MW: 161.2
EINECS: 208-768-0
Assay: 99.5%
Appearance: White crystalline powder
Density: 99%
Melting Point: 210 - 212 °C
Solubility: 2500 g/L (20 °C)
Alpha:-31 º (c=10, H2O)
Storage Temperature: 2-8°C
Refractive index: -32 ° (C=1, H2O)
Origin: China
Export Markets: Global


Description

L-carnitine occurrs mainly in red meat (beef, lamb), in small amounts also in white meat (chicken, turkey).Only very small quantities are found in vegetarian foods. Vegetarians and Vegans thus usually have very low L-carnitine levels.It is most sensible as a food supplement for people, who are mentally and physically very active, on a diet or vegetarians.

 

Chemical Properties

It is transparent or white crystalline powder, m.p. 200 ℃ (decomposition). It is easily soluble in water, alkaline, methanol and ethanol but nearly insoluble in acetone and acetate and insoluble in chloroform. It is hygroscopicity. Rabbit: oral LD50: 2272-2444mg/kg, ADI 20mg / kg.

 

Application and prospect of functional food

L-carnitine, as a new kind of nutritional supplements, especially as the additive of baby formula, athlete food, and food for losing weight and bodybuilding, has been currently widely applied in functional foods. The commercialized L-carnitine is mainly its hydrochloric acid salt, tartaric acid salt and citric acid magnesium salts.

 

1. Application in infant formula food

L-carnitine plays an important role in the baby’s metabolism process of taking fat as a source of energy. Owing to that the weak ability of baby of de no biosynthesis of L-carnitine can’t meet the demands of its normal metabolism, it must be ingested exogenous L-carnitine base in order to ensure the best in body fat oxidation state and provide enough energy to maintain normal body temperature of the baby. In addition, L-carnitine also has certain effects on boosting infant growth and development and improving metabolic balance. So it is necessary to strengthen the


L-carnitine in infant food, especially in soy-based infant formula. Because of the low carnitine content in soy, the limit of L-carnitine content in infant formula food is 70 ~ 90mg/kg in China. Now China has carnitine fortified infant formula milk that has entered into market.

 

2. Application of athletes Food

Decombaz J. et al have reported that after fierce exercise, the free carnitine content in human muscle tissue will decrease by 20% and the supplemental of carnitine can alleviate the fatigue of the body because L-carnitine can promote fat oxidation of the body as well as provide sufficient energy which is good for the sports endurance as well as explosiveness improvement. If L-carnitine is used in combination with octacosanol, then the effect of improving the body strength would be multiplied, manifested as the systemic muscles relaxation, improved explosive power and endurance, and increased basal metabolic rate as well as improved nutritional status of the myocardium. Commonly used method is to add L-carnitine to athletes’ beverage.

 

3. Application in the food for losing weight

In the early 70s, there had been patent reported of using DL- carnitine for the prevention and treatment of obesity. Subsequently, because of the negative effect, DL-carnitine was replaced by L-carnitine. Practice has proved that L-carnitine fortified food has good effect on treating the fat metabolism disorder caused by carnitine deficiency in vivo. It can prevent obesity and fatty liver due to the accumulation of lipids in the liver and muscle fibers. Kuwata thought that obesity patients due to lack of exercise have large amount of accumulated fat and have low carnitine biosynthesis capability. Through ingestion of L-carnitine, they can effectively convert excess body fat into energy to be released, thus playing a role in prevention and treatment of obesity. Thereby the lipid-lowering food with L-carnitine as the main component becomes very popular in the European marke

 

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