Lamivudine CAS 134678-17-4

Lamivudine CAS 134678-17-4

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details

Lamivudine CAS 134678-17-4

Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Basic information
CAS No:134678-17-4                                                          Einecs No.:   N/A
Character:White to off-white  powder                           MF:C8H11N3O3S
MW:229.25                                                                         Purity:99%
Quality Guarantee Period:Two Years Min                      Grade Standard:enterprise standard
Sample:10-20g Free Sample                                             Brand Name:Wongpharm




Lamivudine CAS 134678-17-4
Specification: USP
Molecular formula:C8H11N3O3S
Character:White to off-white  powder
 

pharmacological toxicology:
lamivudine is a nucleoside antivirals.It has a strong inhibitory effect on the hepatitis b virus in vitro and in experimental infected animals.Lamivudine may be metabolized within infected cells and normal cells lamivudine triphosphate, it is the active form of lamivudine, is viral polymerase inhibitors, can quickly inhibit the replication of the virus.Lamivudine triphosphate seeps into the viral DNA strand and blocks the synthesis of viral DNA.Lamivudine triphosphate does not interfere with the metabolism of normal cell deoxynucleoside, and the inhibition of DNA polymerase alpha and beta in mammalian DNA has little effect on the DNA content of mammalian cells.Lamivudine has no obvious toxicity to mitochondrial structure, DNA content and function

pharmacokinetics:
 lamivudine was well absorbed after oral administration, and oral lamivudine 0.1g was estimated to be about 1 hour for blood peak concentration (Cmax), 1.1 ~ 1.5 ug/ml, and biological utilization was 80% ~ 85 %.Lamivudine and food can delay between 0.25 ~ 2.5 hours and the concentration of blood drug peak (Cmax) by 10 ~ 40%, but the bioavailability remains unchanged.Intravenous drug research results show that the average distribution of lamivudine (Vd) volume of 1.3 L/kg, average system clearance of 0.3 L/h/kg, lamivudine (70%), mainly by the organic cation transport system by renal clearance, blood elimination half-life (t1/2)
For 5 to 7 hours.The pharmacokinetic kinetics of lamivudine was linear in the therapeutic dose range, and the plasma protein binding rate was low.In vitro studies showed that the binding rate of serum albumin was <16% ~ 36%.Lamivudine can enter the cerebrospinal fluid through the blood-cerebrospinal barrier barrier.
Lamivudine is mainly based on the renal excretion of the drug prototype, and the renal excretion is about 70% of the total clearance, and only 5% ~ 10% is metabolized into the derivative of the anti-sulfur oxide.



drug interaction:
1. Lamivudine and have the same discharge mechanism of drugs (such as methyl benzyl oxygen organism, sulfamethoxazole) at the same time, when using lamivudine blood levels can be increased by 40%, but is damage to kidney function.
2. The concentration of blood drug peaks (Cmax) of the latter can be increased with zidovudine, but it does not affect the area under the curve of the elimination and drug.


Indications:
It is applicable to all kinds of virus infection
Usage and dosage:
take oral, 2 mg/kg weight, 1 time a day.
Storage
shade, seal, kept in a cool, dry place
Package:10kg/drum

 




specification

ASSAY ITEMS

SPECIFICATION(USP)

Appearance

White to off-white crystalline powder

Solubility

Soluble in water, sparingly soluble in ethanol, practically insoluble in ethyl acetate

Light Absorption

Not more than 0.0015 (440nm, 4cm cell, 50mg/ml)

Identification

A) The IR Spectrum of test sample corresponds to the standard IR spectrum of Lamivudine

B) The retention time of the major peak in the chromatogram of the test solution corresponds to that in chromatogram of the reference solution, as obtained in the test of Limit of Lamivudine enantiomer.

Water

Not more than 0.2%

Limit of Lamivudine Enantiomer

Not more than 0.3%

Residual Solvents

Ethanol is not more than 0.2%

Triethylamine (TEA) is not more than 0.1%

Dichloromethane is not more than 0.06%

Toluene is not more than 0.089%

N,N-Dimethylformamide is not more than 0.088%

n-Hexane is not more than 0.029%

Total residual solvents not more than 0.3%

Chromatographic Purity

Salicylic acid is not more than 0.10%

Relative retention time at about 0.4 impurity is not more than 0.3%

Relative retention time at about 0.9 impurity is not more than 0.2%

Any other individual impurity is not more than 0.1%

Total impurities

not more than 0.6%

HPLC Assay (Anhydrous basis)

Not less than 98.0% and not more than 102.0%


Our advantages:

1, High quality with competitive price: 
1)Standard: Enterprise Standard
2)All Purity≥99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available. 
2)Secure and discreet shipment. Various transportation methods for your choice. 
3)Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
 
3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 

Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,  caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
We'd like to accept bank transfer, Western Union or Paypal or Moneygram
 
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
 For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7. Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.


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