Leflunomide Powder 75706-12-6

Leflunomide Powder 75706-12-6

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details

Leflunomide powder 75706-12-6

Contacting Information :

Contact person : Thyen

Skype :live:simeiquan-zhang

WhatsApp : +8618038176818

E-mail : zhangyinglong@ycphar.com

Website : www.sellsteroid.com

Product name: Leflunomide
Alias: Leflunomida; Leflunomidum; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomide; lefunamide;
CAS Number: 75706-12-6
Molecular formula: C12H9F3N2O2
Molecular weight: 270.20700
Exact mass: 270.06200 PSA: 55.13000 LogP: 3.32710
Appearance and properties: off-white crystalline solid
Density: 1.392 g/cm3
Melting point: 163-168°C
Boiling point: 289.3oC at 760 mmHg
Flash point: 128.8oC
Storage condition: 2-8oC
Signal Word: Danger
Hazard statement: H301; H315; H319; H335
Cautionary Statements: P261; P301 + P310; P305 + P351 + P338
Customs Code: 2934999090
Dangerous goods transport code: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard category code: R22; R36/37/38
Safety instructions: S26; S36
RTECS number: NY2354200
Dangerous goods mark: Xn

Leflunomide is an isoxazole derivative having antiproliferative activity, which inhibits dihydroorotic acid synthase and inhibits the proliferation of lymphocytes and B cells by inhibiting the entire biosynthesis of pyrimidines. In addition, this product can also inhibit the activity of tyrosine kinase, inhibit the activation of nuclear factor-KB and gene expression, inhibit the expression of cytokines, adhesion molecules, inhibit the production and secretion of antibodies and NO production, so it has anti-inflammatory effect .

For the treatment of adult rheumatoid arthritis and lupus nephritis. Can also be used for bullous pemphigoid, connective tissue disease, Wegener's granulomatosis, severe psoriasis and so on.

Adverse reactions mainly included diarrhea, pruritus, and reversible elevations in ALT/AST. If leukopenia occurs, it should be reduced or deactivated. Males who are preparing to give birth should consider discontinuing medication while taking cholestyramine. Excessive doses or toxicities can be eliminated with cholestyramine or activated charcoal.

Pregnancy and lactation women are disabled. Immune defects, uncontrolled infections, active gastrointestinal disorders, renal insufficiency, and myelodysplasia are contraindicated.
Rare interstitial pneumonia is used with caution in patients with lung disease. There is no data on the efficacy and safety of children. It is recommended that individuals younger than 18 years old do not use it.

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