Leflunomide is an isoxazole derivative having antiproliferative activity, which inhibits dihydroorotic acid synthase and inhibits the proliferation of lymphocytes and B cells by inhibiting the entire biosynthesis of pyrimidines. In addition, this product can also inhibit the activity of tyrosine kinase, inhibit the activation of nuclear factor-KB and gene expression, inhibit the expression of cytokines, adhesion molecules, inhibit the production and secretion of antibodies and NO production, so it has anti-inflammatory effect .
application For the treatment of adult rheumatoid arthritis and lupus nephritis. Can also be used for bullous pemphigoid, connective tissue disease, Wegener's granulomatosis, severe psoriasis and so on.
Precautions Adverse reactions mainly included diarrhea, pruritus, and reversible elevations in ALT/AST. If leukopenia occurs, it should be reduced or deactivated. Males who are preparing to give birth should consider discontinuing medication while taking cholestyramine. Excessive doses or toxicities can be eliminated with cholestyramine or activated charcoal.
Taboo Pregnancy and lactation women are disabled. Immune defects, uncontrolled infections, active gastrointestinal disorders, renal insufficiency, and myelodysplasia are contraindicated. Rare interstitial pneumonia is used with caution in patients with lung disease. There is no data on the efficacy and safety of children. It is recommended that individuals younger than 18 years old do not use it.