Naphazoline hydrochloride / CAS:550-99-2
Product Name:Naphazoline hydrochloride
Synonyms:naphconforte;naphthasoliumchloride;niazol;privinehydrochloride;prizolehydrochloride;rhinantin;rhinoperd;sanorin-spofa
CAS:550-99-2
MF:C14H15ClN2
MW:246.74
EINECS:208-989-2
mp:254-260 °C
Water Solubility:170 g/L (20 ºC)
Usage:adrenergic blocker,antihistamine
Naphazoline hydrochloride brief introduction:
Naphazoline (in the hydrochloride form) is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in several over-the-counter formulations including Clear Eyes and Naphcon eye drops.
coa:
ItemsSpecificationsResults
AppearanceWhite crystalline powderPass
Assay99.0%~101.0%99.77%
Melting point254.0~260.0°C254.1~257.7°C
Loss on drying0.50% Max0.10%
pH5.0~6.56
Residue on ignition0.20% max0.08%
Total impuritiesnot more than 2.0%Pass
AlcoholNot more than 300 ppmPass
Product NameNaphazoline hydrochloride
CAS550-99-2
Appearancecolourless oily liquid
StandardUSP/BP
Package25kg/drum or as required
Usageadrenergic blocker,antihistamine
Minimum order quantity1kg
passmentProfessional team special for package and shipment and staring
on tracking code 24hours for customs pass guaranteed
ShippingBy express courier
Shipping leading timeWithin 24 hours after receiving the payment
Payment optionsWestern Union, MoneyGram, T/T,Bank transfer
shipping1)Express delivery with DHL,EMS,Fedex,HKEMS,TNT,UPS
(Express delivery within 24 hours after payment)
2)By sea (large quantity ,it will take 30-45days)
PriceNegotiated
Supply ability500kg/Month
Warnings and contraindications
A few warnings and contraindications that apply to all naphazoline-containing substances intended for medicinal use are:
Hypersensitivity to naphazoline
Patients taking MAO inhibitors can experience a severe hypertensive crisis if given a sympathomimetic drug such as naphazoline HCl
Use in infants and children can result in central nervous system depression, leading to coma and marked reduction in body temperature
Should be used with caution in patients with severe cardiovascular disease including cardiac arrhythmia and in patients with diabetes, especially those with a tendency toward diabetic ketoacidosis
Drug interactions can occur with anaesthetics that sensitize the myocardium to sympathomimetics (e.g. cyclopropane or halothane cautiously)
Exercise caution when applying prior to use of phenylephrine.
Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion.
A possible association with stroke has been suggested.
