Name: Pirfenidone
Synonyms: 5-Methyl-1-phenyl-2-(1H)-pyridone; 5-methyl-1-phenylpyridin-2(1H)-one
Molecular Formula: C12H11NO
Molecular Weight: 185.2218
CAS: 53179-13-8
 

Pirfenidone (PFD) is a novel pyridone compound with a broad-spectrum antifibrotic effect. Its chemical name is 5-methyl-1-phenyl 2-(1H)pyridone, which is a white or Light yellow crystalline powder. It prevents and reverses the formation of fibrosis and scars; it was marketed in 2008 by Shinohara Shirai, and has been approved by the U.S. Food and Drug Administration as the first to pass a repeat, randomized, placebo-controlled Phase III clinical trial A drug that has a certain effect on idiopathic pulmonary fibrosis (IPF); and it is also effective in fibrotic diseases such as renal interstitial fibrosis and hepatic fibrosis; it also has renal disease (focal segmentality). Glomerulosclerosis), hypertrophic cardiomyopathy, adult type I polyneuropathy, juvenile I neurofibromatosis and plexiform neurofibromatosis, diabetes with renal disease, and uterine leiomyoma Clinical research and other aspects are widely used.