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Product Name: Pregnenolone
Synonyms: 3-beta-Hydroxypregn-5-en-20-one; Pregnenolone; Arthenolone;
Molecular Weight: 316.48
Appearance: Pregnenolone is a white to off-white powder
Density: 1.09 g/cm3
Melting Point: 188-190 °C
Boiling Point: 443.3°C at 760 mmHg
Flash Point: 188.9°C
Solubility: Pregnenolone is Insoluble in water
Usage: Pregnenolone contains ketones and hydroxyl functional groups, two methybranches, and a double bond at C5
Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.
Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.
Pregnenolone undergoes further steroid metabolism in one of three ways.
Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in production of 17-hydroxy progesterone and andros tenedione, precursor to test osterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17伪-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandros terone (DH EA) using a desmolase. DH EA is the precursor of andros tenedione.
Pregnenolone can be converted to androsta-5,16-dien-3 beta-ol by 16-ene synthetase.
Pregnenolone is a natural hormone produced within the body, however many different factors can interfere with proper production of this compound. Natural Pregnenolone production declines as we age. For these reasons, many individuals may benefit from boosting levels of this compound using dietary supplement. When the supplement is taken orally, it is able to quickly pass through the blood-brain barrier and enter into the central nervous system.
Pregnenolone is a steroidal hormone with several powerful nootropic benefits.
It is used as a focus booster, mood enhancer and energy pill. Recent studies have found it effective for improving memory, comprehension, and information processing and critical analysis. According to Dr. Flood of the Geriatric Research Education and Clinical Center, "Pregnenolone is the most potent memory enhancer yet reported". Pregnenolone is also one of the most important hormones within the body, involved in the synthesis of many different types of chemicals and other hormones like androgens, estrogens, glucocorticoids, and more. This supplement is considered to be a pro-hormone, which essentially means that it leads to the production, development, or synthesis of a number of other chemicals and hormones.
Pregnenolone is synthesized from cholesterol. This occurs primarily in the adrenal glands, but also within the liver, skin, brain, testicles, ovaries, and retinas (eye). As a steroid, this supplement acts as a precursor to DHEA, progesterone, testosterone, estrogen, and cortisol. Even though this supplement has some very powerful metabolites, it is also considered to be without significant side effects and very limited anabolic, estrogenic, or androgenic activity.
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