Quinine CAS 130-95-0

Quinine CAS 130-95-0

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Product Details

Quinine CAS 130-95-0

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Quick Detail:

Product Name:Quinine
CAS:130-95-0
MF:C20H24N2O2
MW:324.42
EINECS:205-003-2
Product Categories:chiral;Alkaloids;Biochemistry;for Resolution of Acids;Inhibitors;Fluorescent;Quinoline
Mol File: 130-95-0.mol


Description:

Quinine, an alkaloid derived from the bark of the cinchona tree, is a blood schizontocidal agent that is more toxic than chloroquine.Quinine is used to treat malaria caused by Plasmodium falciparum. Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria. Quinine works by killing the parasite or preventing it from growing. This medicine may be used alone or given together with one or more medicines for malaria.
Quinine should not be used to treat or prevent night time leg cramps. This medicine may cause very serious unwanted effects and should only be used for patients with malaria.It is administered parenterally to patients with severe or complicated malaria who cannot take drugs by mouth because of coma, convulsions or vomiting.
It is administered orally to less seriously ill patients with infections likely to be resistant to chloroquine or mefloquine, sometimes in combination with pyrimethamine/sulfadoxine or a tetracycline.
Quinine is an extremely basic compound and is, therefore, always presented as a salt. Various preparations exist, including the hydrochloride, dihydrochloride, sulphate, bisulphate, and gluconate salts; of these the dihydrochloride is the most widely used. Quinine has rapid schizonticidal action against intra-erythrocytic malaria parasites. It is also gametocytocidal for Plasmodium vivax and Plasmodium malariae, but not for Plasmodium falciparum. Quinine also has analgesic, but not antipyretic properties. The anti-malarial mechanism of action of quinine is unknown.

Uses:

Quinine is one of the oldest antimalarial drugs. At as early as the 15th century, the quinine-containing cinchona bark has been used extensively in the treatment of malaria with its antimalarial effect being similar to that of chloroquine that is through interfering with DNA synthesis effect. It is capable of inhibiting the erythrocytic stage of a variety of Plasmodium, being able to control the malaria symptoms. It also has certain killing effect on the gametes of vivax malaria and quartan malaria. However, it has no effect on the exoerythrocytic stage. Its major advantage is not easy to produce drug resistance, possibly due to that quinine binds the plasmodium DNA in a different way from chloroquine, so having no cross-resistance and can be used for the treatment of the infection of anti-chloroquine strains (especially Plasmodium falciparum). In addition, quinine can also exciting the uterus, inhibit the myocardium and have antipyretic analgesic effect. In addition to medicinal application, in analytical chemistry it can be used as the detection agent of bismuth, platinum and other metal ions and also be used for the separation agent of racemic organic acid.

Side effects:

1, cinchona reaction: this can occur when the daily quinine dosage exceeds more than 1g or a little longer, manifested as nausea, vomiting, tinnitus, headache, vision hearing loss, generally being able to be restored after drug withdrawal. 

2, specific reaction: it can be observed of acute hemolysis, dermatitis, itching, angioneurotic edema and bronchial asthma. A small number of patients with falciparum malaria, after administrating quinine, can get chills, fever, vomiting, hemoglobinuria, urinary retention and other acute hemolytic disease, called black urine heat which can be fatal in severe cases.

3, intravenous injection, can inhibit the heart and further cause decreased blood pressure and life-threatening shock, thus it is strictly prohibited to adopt intravenous injection. Intravenous infusion should be administrated with caution. Intramuscular injection is prone to cause tissue necrosis, and thus is generally not used except in cases that oral administration is not doable.


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