Ranitidine Hydrochloride CAS 66357-59-3

Ranitidine Hydrochloride CAS 66357-59-3

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details

Ranitidine Hydrochloride CAS 66357-59-3

Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Product Name:Ranitidine Hydrochloride
Synonyms:ah19065;ranidil;ranigast;Ranitidine hydrochloride USP24;Rantidine hydrochloride USP24;Ranitidine hydrochloride CP2000,USP24;Rantidine HCL;Ranitidine HCL BP2000/USP25
CAS:66357-59-3
MF:C13H23ClN4O3S
MW:350.86
EINECS:266-332-5
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;AntagonistsEPA;NeatsCell Signaling Enzymes;1694 Pharmaceuticals&Personal Care Products;Histaminergics;Neurotransmitters;Substrates;Xenobiotics and Drug Metabolism;SPECTAZOLE;API
Mol File:66357-59-3.mol
Ranitidine Hydrochloride Chemical Properties
Melting point 134°C (dec.)
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility H2O: 1.8 mg/mL
form solid
color tan
Water Solubility Soluble in water, 2-hydroxypropyl-beta-cyclodextrin, acetic acid, methanol, ethanol and dimethyl sulfoxide. Insoluble in chloroform.
Sensitive Hygroscopic
Merck 14,8110
CAS DataBase Reference66357-59-3(CAS DataBase Reference)
Safety Information
Hazard Codes F,T
Risk Statements 20/21/22-39/23/24/25-23/24/25-11
Safety Statements 22-24/25-45-36/37-16-7
WGK Germany 2
RTECS KM6557000
Ranitidine Hydrochloride Usage And Synthesis
Background and overviewRanitidine Hydrochloride (RHCl) is a kind of histamine H2 receptor antagonist. Since its listing in 1981, ranitidine hydrochloride has been widely used in nearly one hundred countries in the world, including China. It is clinically used for the treatment of duodenal ulcer, reflux esophagitis and Zollinger-Ellison syndrome. It is also used for the prevention of gastrointestinal bleeding caused by stress ulcer and recurrent hemorrhage of peptic ulcer. In recent decade, through the combination of ranitidine and other drugs, it has found that it has high efficiency and remarkable features in the treatment of Helicobacter pylori-positive duodenal ulcer, urticaria and post-cerebral hemorrhage stress ulcer with better efficacy than other similar drugs. Owing to its rapid effect, good potency and low price, ranitidine hydrochloride plays an important role in the anti-ulcer drug market today. Therefore, strict quality control plays important roles in guiding patients with reasonable, safe medication.
Pharmacological effectsThis product is a H2 receptor inhibitor, being capable of inhibiting the gastric acid secretion. After oral administration, it is absorbed through the gastrointestinal tract quickly. Synthetic route [4]
The intermediates (3) and (5) were synthesized as follows. The intermediates (3) and (5) were then reacted to produce (6) ranitidine. The (6) is subject to purification and salt formation to generate ranitidine hydrochloride, as shown:
PharmacokineticsAfter oral administration, it is absorbed rapidly from the gastrointestinal tract with a bioavailability (F) of about 50% and peak plasma concentration (tmax) reaching within 1 to 2 hours. Plasma protein binding rate is 15% ± 3%; effective blood concentration is 100ng / ml, widely distributed in the body with the apparent volume of distribution (Vd) of 1.1 ~ 1.9L / Kg. It can penetrate through the blood - brain barrier with the drug concentration in cerebrospinal fluid being 1/30 ~ 1 / 20 of blood concentration. 30% is subject to liver metabolism with the metabolites including N-oxide, S-oxide and demethylation metabolites. 50% of the prototype is subject to urine excretion through kidney. Half-life (t1 / 2) is 2 to 3 hours, which is similar to cimetidine. Renal failure causes corresponding increase in the half-life. The goods can be transplanted via the placenta with the milk concentration being higher than the plasma concentration of drugs.
IndicationsFor the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other high acid secretion disorders.
Adverse reactions
  • Common reactions are: nausea, rash, constipation, fatigue, headache, dizziness and so on.

  • Light adverse reactions on the renal function, gonadal function and central nervous system.

  • A small number of patients get mild liver damage after taking the drug with the symptoms disappearing after stopping, liver function returned to normal.

Medicine interactions
  • Combination with procainamide reduces the clearance rate of the later one.

  • Drug interactions may occur if used with other medications, consult physician or pharmacist for details.

Precautions
  • This product mustn't be used continuously for more than 7 days, the symptom is not relieved, consult your physician or pharmacist.

  • Elderly patients or patients with liver and kidney dysfunction use with caution.

  • If overdose or serious adverse reactions, should seek medical treatment immediately.

  • Disable it for people who are allergic to this product; allergies should use with caution.

  • This product is not allowed for administration upon change of its traits.

  • Please put this product where children cannot touch.

  • Children must be under adult guardianship. 

  • If you are using other drugs, please consult your physician or pharmacist before using this product.

Contraindication
  • Children under 8 years should be disabled.

  • Pregnant and lactating women should be disabled.

Elderly patients medicationThe elderly have reduced liver and kidney function; in order to ensure drug safety, dosage should be adjusted.
Chemical PropertiesOff-White Crystalline Solid
UsesA histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.
Usesantifungal
Contact allergensRanitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.


Our advantages:

1, High quality with competitive price: 
1)Standard: Enterprise Standard
2)All Purity≥99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available. 
2)Secure and discreet shipment. Various transportation methods for your choice. 
3)Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
 
3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 

Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,  caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
We'd like to accept bank transfer, Western Union or Paypal or Moneygram
 
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
 For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7. Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.


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