Spironolactone Of Synthetic 17-lactone Steroid For Antihypertensive

Spironolactone Of Synthetic 17-lactone Steroid For Antihypertensive

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Product Details


Spironolactone CAS:52-01-7

Spironolactone MF:C24H32O4S

Spironolactone MW:416.57

Spironolactone EINECS:200-133-6

Spironolactone mp:207-208 °C(lit.)

alpha:-37 º (c=1, CHCl3)

Spironolactone refractive index:-36 ° (C=1, CHCl3)

Spironolactone Chemical Properties:White to Off White Solid

Spironolactone Usage:It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia

Usagediuretic, aldosterone antagonist

Biological Activity:Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo . Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Spironolactone COA

Test Items                                   Specification                                        Test Results

Appearance                                Almost white crystalline powder           Almost white crystalline powder

Identification                               Meet the requirements                        Meet the requirements

Melting                                        range198℃~209℃                 205.0℃~207.0℃

Specific rotation                          -33°~-37°                                        -35°

Loss on drying                            ≤0.5%                                                0.2%

Limit of mercapto compounds     Meet the requirements                         Meet the requirements

Ordinary impurities                      Meet the requirements                         Meet the requirements

Organic volatile impurities           Meet the requirements                        Meet the requirements

Assay(on the dried basis)           97.0%~103.0%(C24H32O4S)                  98.99%

Conclusion                                  Meet the requirements of USP29

Spironolactone Product Tags:Spironolactone、52-01-7

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