Spironolactone
Spironolactone CAS:52-01-7
Spironolactone MF:C24H32O4S
Spironolactone MW:416.57
Spironolactone EINECS:200-133-6
Spironolactone mp:207-208 °C(lit.)
alpha:-37 º (c=1, CHCl3)
Spironolactone refractive index:-36 ° (C=1, CHCl3)
Spironolactone Chemical Properties：White to Off White Solid
Spironolactone Usage：It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia
Usagediuretic, aldosterone antagonist
Biological Activity：Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo . Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
Spironolactone COA
Test Items Specification Test Results
Appearance Almost white crystalline powder Almost white crystalline powder
Identification Meet the requirements Meet the requirements
Melting range198℃~209℃ 205.0℃~207.0℃
Specific rotation -33°~-37° -35°
Loss on drying ≤0.5% 0.2%
Limit of mercapto compounds Meet the requirements Meet the requirements
Ordinary impurities Meet the requirements Meet the requirements
Organic volatile impurities Meet the requirements Meet the requirements
Assay(on the dried basis) 97.0%~103.0%(C24H32O4S) 98.99%
Conclusion Meet the requirements of USP29
Spironolactone Product Tags：Spironolactone、52-01-7