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Synonyms: 1-beta-d-arabinofuranosyl-uraci ;1-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;1-beta-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione;Spongouridine;Uridine;1--D-Arabinofuranosyl-2,4(1H,3H)-pyrimidinedione;NSC 68928;1-(β-D-Arabinopyranosyl)uracil
storage temp. 2-8°C
Color: White to Off-white
Vidarabine is an antiviral, active against herpes viruses, poxviruses, rhabdoviruses, hepadnaviruses and some RNA tumour viruses. A 3% ophthalmic ointment Vira-A is used in the treatment of acute keratoconjunctivitis and recurrent superficial keratitis caused by HSV-1 and HSV-2. Vidarabine is also used to treat herpes zoster in AIDS patients, reducing lesions formation and the duration of viral shedding.
Many of the previous uses of vidarabine have been superseded by acyclovir, due to the hospitalisation required for intra venous dosing, and acyclovir has a higher selectivity, lower inhibitory concentration and higher potency. Toxic side effects are rare, but have been reported with high concentrations of vidarabine, such as nausea, vomiting, leukopenia and thrombocytopenia in patients receiving high intravenous doses daily.
Arabinoside is also used to treat herpes zoster in AIDS patients,
reducing the incidence of disease and virus shedding time. Many of the previous use of arabinoside has been substituted for acyclovir, due to intravenous administration of the required hospitalization, and acyclovir has a
high selectivity, low bacteriostatic concentration and higher potency. The side effects are rare, but there are reports of high concentrations of arabinoside, such as nausea, vomiting, in patients receiving high doses of intravenous
daily leukocyte and thrombocytopenia.