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What is Tauroursodeoxycholic acid?
Drugs and clinical application Tauroursodeoxycholic acid ,also known as taurocholic ursodeoxycholic acid, the chemical name is 3, 7-dihydroxy bile alkanoyl-N-taurine ,it is mainly present in the black bear bile, It is the active ingredient in bear bile landmark. It has many effects such as antispasmodic, anticonvulsant, anti-inflammatory and dissolve gallstones and so on.
Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile; UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears. TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. UDCA is produced in several countries for the treatment of gallstones and liver cirrhosis. It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis. Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's disease, and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.
How does Tauroursodeoxycholic acid work?
Tauroursodeoxycholic acid is a natural bile acid separated from the bear bile,it is a chemical, in the body it is combined with taurine to be present in bile, it is a hydrophilic acid, as a cholesterol gallstones dissolving agent.it Can reduce the secretion of cholesterol in the liver, and lower cholesterol saturation of bile, and promote the secretion of bile acids and it can increase the solubility of cholesterol in the bile, so that it can make cholesterol gallstones dissolve or prevent the formation of stones. It can Increase the secretion of bile, and relax bile duct mouth sphincter to produce choleretic effect, it is conducive to discharge stones. This product can not dissolve other types of gallstones.It is useful in the treatment of cholesterol stones, hyperlipidemia, bile secretion disorders, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis and prevention of liver allograft rejection and reaction. Litholysis effect of this product is slightly weaker than the CDCA.
What is usage of Tauroursodeoxycholic acid?
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways.