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Synonyms:Tauroursodiol;Urosodeoxycholic Acid;Ursodeoxycholic acid(micronized);(3a,5b,7b)-3,7-Dihydroxycholan-24-oic acid;7BETA-HYDROXYLITHOCHOLIC ACID;6BETA-CHOLANIC ACID-3A,7BETA-DIOL;(6-BETA)-CHOLANIC ACID-(3-ALPHA)-(7-BETA)-DIOL;3A,7B-DIHYDROXY-5B-CHOLAN-24-OIC ACID
Melting point:203-204 °C(lit.)
alpha 60 º (c=2, EtOH)
refractive index 60.5 ° (C=2, EtOH)
storage temp. Refrigerator
solubility ethanol: 50 mg/mL, clear
color Clear colorless
Water Solubility practically insoluble
1. Tauroursodeoxycholic acid is white powder, almost insoluble in water, freely soluble in alcohol
Use: Ursodeoxycholic acid Ursodiol is used for the dissolution of cholesterol gallstones and prevention of drug-induced gallstones. Ursodeoxycholic acid can also be used for the treatment of stearrhea.
2. Tauroursodeoxycholic acid TUDCA 14605-22-2 Ursodiol also known as ursodiol, is a compound produced from bile by the action of intestinal bacteria. Since this bile acid is not produced directly by the body, it is known as a secondary bile acid. One of the functions of bile acids is to act in the intestine to help digest fats and fat-soluble vitamins from food. Ursodeoxycholic acid has been used in pharmacology to dissolve gallstones made of cholesterol, and to treat liver disorders. It has been used for a long time in both human and veterinary medicine.
Used as an anticholelithogenic . Epimer with Chenodiol with respect to the hydroxyl group at C7 Gallstone dissolving drugs. Mainly used in the treatment of inoperable cholesterol gallstones, especially basic gallbladder function properly, stones 15mm or less in diameter, through X-ray, non-calcified cholesterol stones floating high cure rate. Of toxic hepatitis, cholecystitis, primary sclerosing cholangitis, primary biliary cirrhosis of liver also have some therapeutic effect. Improve the efficacy of α- interferon treatment of chronic hepatitis C. Diarrhea, constipation rare, allergic reactions, itching, headache, dizziness, stomach pain, pancreatitis, and bradycardia. Biliary complete obstruction and severe liver dysfunction and pregnant women hanged.
Ursodeoxycholic acid isolated out a chemical natural bile acid, is the difference between CDCA to stereoisomers, its RONGSHI action, efficacy and chenodeoxycholic acid are similar, but short course small dosage. In vivo binding taurine is present in bile acid is a hydrophilic, as a cholesterol gallstone dissolving agent. Can reduce the secretion of cholesterol the liver, reduce cholesterol saturation of bile, stimulates bile acids increase the solubility of cholesterol in the bile, cholesterol stones dissolve or prevent the formation of stones.
Increase the secretion of bile, bile duct mouth sphincter relaxation produce gallbladder, it is conducive to the stones. This product can not dissolve other types of gallstones. Ursodeoxycholic acid useful in the treatment of cholesterol stones, hyperlipidemia, bile secretion disorders, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis and prevention of liver allograft rejection and reaction. RONGSHI effect of this product is slightly weaker than the CDCA.
White or almost white powder
A. Comparable IR absorption with the reference.
Specific optical rotation
+58.0º ~ +62.0º
Loss on drying
Related substances(TLC )
Assay (C 24 H 40 O 4 )
99.0% ~ 101.0%(as dry basis)
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