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Tolazoline hydrochloride Description
Tolazoline hydrochloride is a combination alpha-one and alpha-two antagonist developed to reverse the sedation and analgesia effects of xylazine hydrochloride. Tolazoline hydrochloride was developed and marketed for use in horses by Lloyd Laboratories in the 1990s. It was approved under the trade name Tolazine in 1996. Prior to this tolazoline was available as the human formulation trademarked Priscoline at a concentration of 25 mg/ml from Novartis.
Tolazoline HCl is used in horses to reverse the effects of sedation and analgesia from xylazine HCl. Studies conducted by Lloyd Laboratories have demonstrated efficacy of tolazoline in reversing xylazine sedation in cattle.
Tolazoline hydrochloride belongs to the synthetic group of alpha-adrenergic blocking agents known as imidazole derivatives. It is a mixed alpha-1 and alpha-2 adrenergic receptor antagonist that competitively inhibits alpha-adrenoreceptors. Tolazoline is also a direct peripheral vasodilator that decreases peripheral resistance and increases venous capacitance. Chemically, tolazoline hydrochloride is 1H-imidazole,4,5-dihydro-2-(phenylmethyl)-monohydrochlroide.
Tolazoline hydrochloride belongs to the synthetic group of alpha-adrenergic blocking agents known as imidazole derivatives. It is a mixed alpha-1 and alpha-2 adrenergic receptor antagonist that competitively inhibits alpha-adrenoreceptors. Tolazoline is also a direct peripheral vasodilator that decreases peripheral resistance and increases venous capacitance.
Tolazoline hydrochloride Dosage
The tolazoline hydrochloride dose is 4.0 mg/kg body weight or 1.8 mg/lb. (4ml/100kg or 4ml/220 lb.) to reverse the sedative effects of xylazine hydrochloride in horses.
In studies with cervids, a dose of 2mg/kg of tolazoline to reverse xylazine in deer, resulted in a reduced time to standing.
Tolazoline hydrochloride should be administered slowly by intravenous injection at a rate of approximately 1 ml per second. Onset of arousal is usually apparent within 5 minutes of tolazoline hydrochloride administration, depending on depth and duration of xylazine-induced sedation .
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