Contact : Mr.Thyen
Email us at firstname.lastname@example.org
Whatsapp : +86 180 3817 6818
Tolazoline hydrochloride Description
Tolazoline hydrochloride is a combination alpha-one and alpha-two antagonist developed to reverse the sedation and analgesia effects of xylazine hydrochloride. Tolazoline hydrochloride was developed and marketed for use in horses by Lloyd Laboratories in the 1990s. It was approved under the trade name Tolazine in 1996. Prior to this tolazoline was available as the human formulation trademarked Priscoline at a concentration of 25 mg/ml from Novartis.
Tolazoline HCl is used in horses to reverse the effects of sedation and analgesia from xylazine HCl. Studies conducted by Lloyd Laboratories have demonstrated efficacy of tolazoline in reversing xylazine sedation in cattle.
Tolazoline hydrochloride belongs to the synthetic group of alpha-adrenergic blocking agents known as imidazole derivatives. It is a mixed alpha-1 and alpha-2 adrenergic receptor antagonist that competitively inhibits alpha-adrenoreceptors. Tolazoline is also a direct peripheral vasodilator that decreases peripheral resistance and increases venous capacitance. Chemically, tolazoline hydrochloride is 1H-imidazole,4,5-dihydro-2-(phenylmethyl)-monohydrochlroide.
Tolazoline hydrochloride belongs to the synthetic group of alpha-adrenergic blocking agents known as imidazole derivatives. It is a mixed alpha-1 and alpha-2 adrenergic receptor antagonist that competitively inhibits alpha-adrenoreceptors. Tolazoline is also a direct peripheral vasodilator that decreases peripheral resistance and increases venous capacitance.
Tolazoline hydrochloride Dosage
The tolazoline hydrochloride dose is 4.0 mg/kg body weight or 1.8 mg/lb. (4ml/100kg or 4ml/220 lb.) to reverse the sedative effects of xylazine hydrochloride in horses.
In studies with cervids, a dose of 2mg/kg of tolazoline to reverse xylazine in deer, resulted in a reduced time to standing.
Tolazoline hydrochloride should be administered slowly by intravenous injection at a rate of approximately 1 ml per second. Onset of arousal is usually apparent within 5 minutes of tolazoline hydrochloride administration, depending on depth and duration of xylazine-induced sedation .
1. Rich experience. Having been specialized in this field for years,we have rich experience and
widespread sales network around the word. Our steroid and hormones have been exported to overseas, like Europe, Africa, Asia, America and other countries. We are not got good feedback from our guest, but also established long business relationship with them.
2. Great quality and high purity. Good quality is one secret for our success. All of our products enjoys high purity. Thus, it can make sure our client's need. Welcome order the samples, MOQ just 10 grams.
3. Safest and fastest delivery. We have mass stock, so that we can arrange the delivery within 24hours once receiving the payment. Tracking number would be informed quickly after shipment. We have our own way of packing which could ship 0.01 kilo to 50 kilo products a time.
4. Good after-sales service. 24/7 is available. We will tell you the package updated info ASAP. And try our best to solve various problems customers encountered!
5. Experiential shopping. Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how to make hormone solution on the site. Any visit to our lab is welcomed