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Unifiram nootropic unifiram powder,
Application:Alzheimers Dementia, Treatment of , Cognition Disorders, Treatment of, NEUROLOGIC DRUGS
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his compound is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the Glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).
This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C (PKC). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCactivation through Src kinase. Enhancement of PKC activity triggers to potentiate hippocampal LTP through CaMKII activation.
Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.
Memory Enhancement Drug Powder CAS 314728-85-3 Nootropics Sunifiram
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All sell steroids with USP/BP/EP Standard and Purity reach 98.57%min
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