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Norethisterone (or norethindrone) (or 19-nor-17-ethynyltestosterone) is a molecule used in some combined oral contraceptive pills, progestogen only pills and is also available as a standalone drug. It is a progestogen and can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with oestrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or presurgical gynecologic cases.
Norethindrone was the first orally highly active progestin to be synthesized. It was synthesized for the first time by chemists Luis Miramontes, Carl Djerassi, and George Rosenkranz at Syntex in Mexico City in 1951. I t was the progestin used in one of the first three oral contraceptives. Its related ester, norethisterone acetate, is used for the same indications Customs clearance Don't have to worry about customs pass rate,our customs clearance is 100%
Product Name: Norethindrone
Product Categories: Active Pharmaceutical Ingredients;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;progestogen estrogen;MICRONOR
MP 205-206 °C(lit.)
storage temp. -20°C Freezer
solubility chloroform: ≥50 mg/mL, clear, colorless
color Off-White to Pale Yellow Solid
CAS DataBase Reference 68-22-4(CAS DataBase Reference)
NIST Chemistry Reference Norethindrone(68-22-4)
EPA Substance Registry System 19-Norpregn-4-en- 20-yn-3-one, 17-hydroxy-, (17.alpha.)-(68-22-4)
Hazard Codes Xn
Risk Statements 40-36/37/38-20/21/22
Safety Statements 22-36/37/39-45-37/39-26
Hazardous Substances Data 68-22-4(Hazardous Substances Data)
Norethisterone Usage And Synthesis:
Usage Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen
Raw materials Tetrahydrofuran
Preparation Products 19-Nor-17-alpha-pregna-3,5-dien-20-yne-3,17-diol, diacetate
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