Formestane Lentaron Powder

Formestane Lentaron Powder

Contact : Mr.Thyen------------------------------- Email us at zhangyinglong@ycphar.com Whatsapp : +86 180 3817 6818

Product Details


Formestane


Contact : Mr.Thyen

Email us at zhangyinglong@ycphar.com

Whatsapp : +86 180 3817 6818


Anti Estrogen Medication Formestane CAS:566-48-3 For Treating Breast Cancer

Formestane Details:

Alias

Lentaron, 4-hydroxyandrost-4-ene-3,17-dione

CAS

566-48-3

Appearance

off-white crystalline powder

MF

C19H26O3

MW

302.41

Usage

An antitumor drug. An aromatase inhibitor

Dosage

250mg, 1 time every two weeks, as the arm deep intramuscular injection.

Density

1.19 g/cm3

Melting Point

199-202 ℃

Boiling Point

475.4 ℃ at 760 mmHg

Flash Point

255.4 ℃

Packing

Foil bag or as requirments

Grade

Pharmaceutical Grade


Description

Formestane (trade name Lentaron), also known as 4-hydroxyandrost-4-ene-3,17-dione, is a type I, steroidal, selective aromatase inhibitor.[1] It is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced. Formestane is an analogue of androstenedione.


Formestane is often used to suppress the production of estrogens from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a weak aromatase inhibitor.

 

Formestane Application:

Formestane is a second generation, irreversible, steroidal aromatase inhibitor. It inhibits the aromatase enzyme responsible for converting androgens to estrogens, thereby preventing estrogen production. Breast cancer may be estrogen sensitive or insensitive. A majority of breast cancers are estrogen sensitive. Estrogen sensitive breast cancer cells depend on estrogen for viability.


Thus removal of estrogen from the body can be an effective treatment for hormone sensitive breast cancers. Formestane has been targeted specifically for the treatment of postmenopausal women. Unlike premenopausal women who produce most estrogen in the ovaries, postmenopausal women produce most estrogen in peripheral tissues with the help of the aromatase enzyme. Formestane, an aromatase inhibitor, can thus help to decrease the local production of estrogen by blocking the aromatase enzyme in peripheral tissues (ie. Adispose tissue of the breast) to treat hormone sensitive breast cancer.


Formestane COA

TEST ITEMS

SPECIFICATION

RESULTS

Description

White or Almost White Crystalline Powder

white powder

Identification

A.B.

Positive

Assay

97.0~103.0%

99.3%

Specific Rotation

+101°~+105°

+102.6°

Loss On Drying

1.0%max

0.27%

Melting Point

153~157°C

153.0~155.0°C

Organic Volatile Impurities

meets the requirement.

Conforms

Related Substances

meets the requirement.

Conforms

Residual Solvents

meets the requirement.

Conforms

Particle Size

100% ≤ 20 microns

Conforms

Conclusion

The specification conform with USP30 standard


Formestane Dosages

The most common version of formestane sold was in a topical gel form and it was dosed at 100-200mgs per application. Users would apply it onto clean, dry skin and rub in thoroughly; usually on the thighs or upper arms. It took 1 to 5 minutes to dry.

The injectable version for both breast cancer purposes and bodybuilders is 125mgs twice per week or 250mgs once per week.


Our advantage:

1. We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;

2. Quality: Our company is a professional leading factory in China in pharmaceutical area, We had stable customers and exported to Germany, Spain, UK, USA, Australia, Middle East, and any other countries. We can provide good references about our company. As for the quality of the products, we 're sure they can satisfy you well enough;

3. Package: Professional packing with professional materials;

4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days;

5. Service: Best Service with after-sales service and consultation.


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